Monocast 10 mg (Tablet)

Title

• Monocast 10 mg Tablet

Categories

• Medicine
• Pharmaceutical

Description

• Selective and orally active leukotriene receptor antagonist
• Indicated for prophylaxis and chronic treatment of asthma
• Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
• Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Dosage

• Montelukast 10 mg tablet once daily for adults and adolescents 15 years of age and older
• Montelukast 5 mg tablet once daily for pediatric patients 6 to 14 years of age
• Montelukast 4 mg tablet once daily for pediatric patients 2 to 5 years of age
• Montelukast 4 mg oral granules once daily for pediatric patients 6 months to 5 years of age
• No dosage adjustment in patients with mild-to-moderate hepatic insufficiency or renal insufficiency. No dosage adjustment in the elderly is required.

Interaction

• No clinically important effects on the pharmacokinetics of various drugs including theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin, and warfarin
• Used concomitantly with a wide range of commonly prescribed drugs without evidence of clinical adverse interactions
• Phenobarbital decreased the AUC of Monocast approximately 40% following a single dose
• No dosage adjustment for Monocast is recommended when administered with potent cytochrome P450 enzyme inducers

Contraindications

• Hypersensitivity to any component of this product

SideEffects

• Common: Diarrhoea, fever, gastrointestinal discomfort, headache, nausea, vomiting
• Uncommon: Akathisia, anxiety, arthralgia, asthenia, abnormal behavior, depression, dizziness, drowsiness
• Rare: Angioedema, concentration impaired, disorientation, eosinophilic granulomatosis with polyangiitis, erythema nodosum, hallucination, hepatic disorders, memory loss, palpitations, pulmonary eosinophilia, suicidal tendencies, tremor

PregnancyAndLactation

• Use during pregnancy only if clearly needed
• Caution should be exercised when given to a nursing mother

PrecautionsAndWarnings

• Not indicated for use in the reversal of bronchospasm in acute asthma attacks
• Appropriate rescue medication should be available
• Therapy can be continued during acute exacerbations of asthma
• Should not be abruptly substituted for inhaled or oral corticosteroids
• Should not be used as monotherapy for the treatment and management of exercise induced bronchospasm
• Not shown to truncate bronchoconstrictor response to aspirin and other non-steroidal anti-inflammatory drugs in aspirin-sensitive asthmatic patients

OverdoseEffects

• Adverse experiences consistent with the safety profile of Monocast including abdominal pain, somnolence, thirst, headache, vomiting, psychomotor hyperactivity

TherapeuticClass

• Leukotriene receptor antagonists

StorageConditions

• Store in cool & dry place below 30°C, protect from light & moisture
• Keep out of reach of children

ChemicalStructure

• Molecular Formula: C35H36ClNO3S
• Chemical Structure Image: Available

CommonQuestionsAndAnswers

• What is Monocast 10 mg Tablet?
• What is Monocast 10 mg Tablet used for?
• How soon can the effect be observed?
• How long does the effect last?
• Should I use it empty stomach?
• What if I miss a dose?
• Are there any pregnancy warnings?
• General Instructions

Indications

• Prophylaxis and chronic treatment of asthma
• Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
• Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Pharmacology

• Selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene receptor (CysLT1)
• Cysteinyl leukotrienes and leukotriene receptor occupation correlated with the pathophysiology of asthma & allergic rhinitis
• Inhibition of airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process

HepaticInsufficiency

• No dosage adjustment required

RenalInsufficiency

• No dosage adjustment recommended

ElderlyUse

• Similar pharmacokinetic profile and oral bioavailability as in younger adults
• Slightly longer plasma half-life
• No dosage adjustment required

DrugClasses

• Leukotriene receptor antagonists

CompoundSummary

• Molecular Formula: C35H36ClNO3S
• Chemical Structure Image: Available

MissedDoseInstructions

• If missed, take as soon as possible. If almost time for next dose, skip that dose
• Do not double up on doses

PharmacyInstruction

• Take exactly as prescribed
• Do not change dose or stop using asthma medication without doctor's advice
• Not a fast-acting rescue medicine for asthma attacks
• Avoid situations or activities that may trigger an asthma attack
• Seek medical attention if breathing problems worsen quickly
• Talk to doctor before using if pregnant or breastfeeding

Related Brands

• Monocast 4 mg/3.5 gm (Oral Granules) - beximco-pharmaceuticals-ltd
• Monovas 10 mg (Tablet) - the-white-horse-pharmaceuticals-ltd
• Monprox 10 mg (Tablet) - rangs-pharmaceuticals-ltd
• Montair 10 mg (Tablet) - incepta-pharmaceuticals-ltd
• Montekast 10 mg (Tablet) - pacific-pharmaceuticals-ltd