Montekast 10 mg (Tablet)

Product Title

• Montekast 10 mg Tablet

Categories

• Asthma Medication
• Allergic Rhinitis Medication
• Leukotriene Receptor Antagonist

Indications

• Prophylaxis and chronic treatment of asthma
• Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
• Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Pharmacology

• Selective and orally active leukotriene receptor antagonist
• Inhibits the cysteinyl leukotriene receptor (CysLT1)
• Inhibits cysteinyl leukotrienes (LTC4, LTD4, LTE4) release from various cells

Dosage & Administration

• Adult dosage: 10 mg tablet once daily
• Adolescent dosage: 10 mg tablet once daily
• Pediatric dosage (6 to 14 years): 5 mg tablet once daily
• Pediatric dosage (2 to 5 years): 4 mg tablet once daily
• Pediatric dosage (6 months to 5 years): 4 mg oral granules once daily
• No dosage adjustment required in mild-to-moderate hepatic insufficiency
• No dosage adjustment recommended in renal insufficiency
• No dosage adjustment required in the elderly

Interaction

• No clinically important effects on the pharmacokinetics of several drugs
• No evidence of clinical adverse interactions with commonly prescribed drugs
• Phenobarbital decreased the AUC of Montekast by approximately 40%

Contraindications

• Hypersensitivity to any component of the product

Side Effects

• Common: Diarrhea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, upper respiratory tract infection
• Uncommon: Akathisia, anxiety, arthralgia, asthenia, abnormal behavior, depression, dizziness, drowsiness, dry mouth, hemorrhage, irritability, malaise, muscle complaints, edema, seizure, abnormal sensation, sleep disorders
• Rare: Angioedema, concentration impaired, disorientation, eosinophilic granulomatosis with polyangiitis, erythema nodosum, hallucination, hepatic disorders, memory loss, palpitations, pulmonary eosinophilia, suicidal tendencies, tremor

Pregnancy & Lactation

• Crosses the placenta in rats and rabbits
• Use during pregnancy only if clearly needed
• Caution should be exercised when given to a nursing mother

Precautions & Warnings

• Not indicated for use in the reversal of bronchospasm in acute asthma attacks
• Should be continued during acute exacerbations of asthma
• Should not be abruptly substituted for inhaled or oral corticosteroids
• Not to be used as monotherapy for the treatment and management of exercise induced bronchospasm
• Patients with known aspirin sensitivity should continue avoidance of aspirin or non-steroidal anti-inflammatory agents while taking Montekast

Overdose Effects

• Adverse experiences consistent with the safety profile of Montekast
• Usual supportive measures recommended in the event of overdose

Therapeutic Class

• Leukotriene receptor antagonists

Storage Conditions

• Store in cool & dry place below 30°C
• Protect from light & moisture
• Keep out of reach of children

Chemical Structure

• Molecular Formula: C35H36ClNO3S
• Chemical Structure: Image provided

Commonly Asked Questions

• What is Montekast 10 mg Tablet?
• What is Montekast 10 mg Tablet used for?
• How soon can the effect of Montekast 10 mg Tablet be observed?
• How long does the effect of Montekast 10 mg Tablet last?
• Should I use Montekast 10 mg Tablet empty stomach?
• What if I miss a dose of Montekast 10 mg Tablet?
• Are there any pregnancy warnings for Montekast 10 mg Tablet?
• General Instructions

Usability Features

• Not a fast-acting rescue medicine for asthma attacks
• Appropriate rescue medication should be available
• Therapy can be continued during acute exacerbations of asthma
• Avoidance of aspirin or non-steroidal anti-inflammatory agents in patients with known aspirin sensitivity

Technical Specifications

• Molecular Formula: C35H36ClNO3S

Compatibility

• No clinically important effects on the pharmacokinetics of several drugs
• No evidence of clinical adverse interactions with commonly prescribed drugs

Allergic Rhinitis Relief

• Relief of symptoms of Allergic Rhinitis: Seasonal & Perennial Allergic Rhinitis

Prophylaxis Functions

• Prophylaxis and chronic treatment of asthma
• Acute prevention of Exercise-Induced Bronchoconstriction (EIB)

Storage Instructions

• Store in cool & dry place below 30°C
• Protect from light & moisture
• Keep out of reach of children

Pregnancy Precautions

• Use during pregnancy only if clearly needed
• Caution should be exercised when given to a nursing mother

Age-specific Dosage

• Adult dosage: 10 mg tablet once daily
• Adolescent dosage: 10 mg tablet once daily
• Pediatric dosage (6 to 14 years): 5 mg tablet once daily
• Pediatric dosage (2 to 5 years): 4 mg tablet once daily
• Pediatric dosage (6 months to 5 years): 4 mg oral granules once daily

Adverse Reactions

• Diarrhea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, upper respiratory tract infection
• Akathisia, anxiety, arthralgia, asthenia, abnormal behavior, depression, dizziness, drowsiness, dry mouth, hemorrhage, irritability, malaise, muscle complaints, edema, seizure, abnormal sensation, sleep disorders
• Angioedema, concentration impaired, disorientation, eosinophilic granulomatosis with polyangiitis, erythema nodosum, hallucination, hepatic disorders, memory loss, palpitations, pulmonary eosinophilia, suicidal tendencies, tremor

Antagonist Type

• Selective and orally active leukotriene receptor antagonist

Allergic Response Management

• Relief of symptoms of Allergic Rhinitis: Seasonal & Perennial Allergic Rhinitis

Chemical Formula

• Molecular Formula: C35H36ClNO3S

Delayed Onset of Action

• Effect can be observed after 1-3 hours of administration

Duration of Effect

• Lasts for an average duration of 24 hours

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