Montril 10 mg (Tablet)

Title

• Montril 10 mg Tablet

Categories

• Medicine
• Asthma Treatment
• Allergic Rhinitis Treatment

Description

• A selective and orally active leukotriene receptor antagonist
• Indicated for prophylaxis and chronic treatment of asthma, acute prevention of Exercise-Induced Bronchoconstriction (EIB), relief of symptoms of Allergic Rhinitis (AR) including seasonal & perennial AR
• Inhibits the cysteinyl leukotriene receptor (CysLT1)
• Leukotriene receptor antagonist
• Crosses placenta in rats and rabbits
• Store in cool & dry place below 30°C, protect from light & moisture

Dosage & Administration

• Adults and adolescents: 10 mg tablet once daily; Pediatric patients: 5 mg for 6 to 14 years, 4 mg for 2 to 5 years, 4 mg oral granules for 6 months to 5 years
• Safety and efficacy established in pediatric patients with asthma 6 months to 14 years of age
• No dosage adjustment required in mild-to-moderate hepatic insufficiency or renal insufficiency; Elderly use possible without dosage adjustment

Indications

• Prophylaxis and chronic treatment of asthma
• Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
• Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Pharmacology

• Inhibits cysteinyl leukotrienes and leukotriene receptor occupation correlated with asthma & allergic rhinitis pathophysiology

Interaction

• Administered with other therapies routinely used in asthma treatment without increase in adverse reactions
• No clinically important effects on the pharmacokinetics of certain drugs observed
• Co-administered with a wide range of commonly prescribed drugs without evidence of clinical adverse interactions
• Phenobarbital decreased the AUC of Montril approximately 40%
• Appropriate clinical monitoring recommended when potent cytochrome P450 enzyme inducers are co-administered

Contraindications

• Hypersensitivity to any component of the product

Side Effects

• Common: Diarrhoea, fever, headache, nausea
• Uncommon: Anxiety, depression, dizziness, dry mouth
• Rare: Angioedema, hallucination, memory loss, tremor

Pregnancy & Lactation

• Use during pregnancy only if clearly needed
• Caution advised when given to a nursing mother

Precautions & Warnings

• Not for use in the reversal of bronchospasm in acute asthma attacks
• Appropriate rescue medication should be available
• Therapy can be continued during acute exacerbations of asthma
• Not to be abruptly substituted for inhaled or oral corticosteroids
• Not to be used as monotherapy for the treatment and management of exercise induced bronchospasm
• Patients with known aspirin sensitivity should continue avoidance of aspirin or non-steroidal anti-inflammatory agents while taking Montril

Overdose Effects

• No adverse experiences in majority of overdosage reports
• Adverse experiences consistent with the safety profile of Montril observed
• Supportive measures like remove unabsorbed material, clinical monitoring, and supportive therapy may be employed

Therapeutic Class

• Leukotriene receptor antagonists

Storage Conditions

• Store in cool & dry place below 30°C, protect from light & moisture
• Keep out of reach of children

Chemical Structure

• Molecular Formula: C35H36ClNO3S
• Chemical Structure available

Common Questions

• What is Montril 10 mg Tablet?
• What is Montril 10 mg Tablet used for?
• How soon can the effect be observed?
• How long does the effect last?
• Should it be used empty stomach?
• What if a dose is missed?
• Are there any pregnancy warnings?
• General Instructions for use

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