Provair 4 mg (Chewable Tablet)

Indications

• Prophylaxis and chronic treatment of asthma
• Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
• Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Pharmacology

• Selective and orally active leukotriene receptor antagonist
• Inhibits the cysteinyl leukotriene receptor (CysLT1)
• Correlated with the pathophysiology of asthma & allergic rhinitis

Dosage & Administration

• 10 mg tablet once daily for adults and adolescents 15 years of age and older
• 5 mg tablet once daily for pediatric patients 6 to 14 years of age
• 4 mg tablet/oral granules once daily for pediatric patients 2 to 5 years of age
• Pediatric use safety and efficacy profiles similar to those seen in adults
• No dosage adjustment required for hepatic or renal insufficiency
• Elderly use: No dosage adjustment required

Interaction

• Administered with other therapies used in the prophylaxis and treatment of asthma with no apparent increase in adverse reactions
• No clinically important effects on the pharmacokinetics of specific drugs
• Used concomitantly with a wide range of commonly prescribed drugs without evidence of clinical adverse interactions
• Phenobarbital decreased the AUC of Provair approximately 40%
• Appropriate clinical monitoring when potent cytochrome P450 enzyme inducers are co-administered with Provair

Contraindications

• Hypersensitivity to any component of this product

Side Effects

• Common: Diarrhoea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, upper respiratory tract infection
• Uncommon: Akathisia, anxiety, arthralgia, asthenia, abnormal behavior, depression, dizziness, drowsiness, dry mouth, haemorrhage, irritability, malaise, muscle complaints, oedema, seizure, abnormal sensation, sleep disorders
• Rare: Angioedema, concentration impaired, disorientation, eosinophilic granulomatosis with polyangiitis, erythema nodosum, hallucination, hepatic disorders, memory loss, palpitations, pulmonary eosinophilia, suicidal tendencies, tremor

Pregnancy & Lactation

• Crosses the placenta following oral dosing in rats and rabbits
• Use during pregnancy only if clearly needed
• Caution should be exercised when given to a nursing mother

Precautions & Warnings

• Not for use in the reversal of bronchospasm in acute asthma attacks
• Appropriate rescue medication should be available
• Therapy can be continued during acute exacerbations of asthma
• Should not be abruptly substituted for inhaled or oral corticosteroids
• Not for monotherapy for the treatment and management of exercise induced bronchospasm
• Caution in patients with known aspirin sensitivity

Overdose Effects

• No adverse experiences in the majority of overdosage reports
• Usual supportive measures recommended in the event of overdose

Therapeutic Class

• Leukotriene receptor antagonists

Storage Conditions

• Store in cool & dry place below 30°C
• Protect from light & moisture
• Keep out of reach of children

Chemical Structure

• Molecular Formula: C35H36ClNO3S
• Chemical Structure: Montelukast Sodium

Common Questions about Provair 4 mg Chewable Tablet

• Selective and orally active leukotriene receptor antagonist
• Used to treat asthma or allergic rhinitis
• Effect can be observed after 1-3 hours of administration
• Lasts for an average duration of 24 hours
• May be taken with or without food as prescribed by doctor
• Use should be avoided in pregnant women unless clearly needed
• General Instructions: Take exactly as prescribed, do not change dose without doctor's advice, not a fast-acting rescue medicine, avoid triggering situations or activities, consult doctor if pregnant or breastfeeding

Related Brands

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