Provair 10 mg (Tablet)

Title

• Provair 10 mg Tablet

Categories

• Asthma Medication
• Allergic Rhinitis Medication

Indications

• Prophylaxis and chronic treatment of asthma
• Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
• Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Pharmacology

• Montelukast is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene receptor (CysLT1)
• Cysteinyl leukotrienes and leukotriene receptor occupation have been correlated with the pathophysiology of asthma & allergic rhinitis, including airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process, which contribute to the signs and symptoms of asthma

Dosage & Administration

• Adults and adolescents dosage: Montelukast 10 mg tablet once daily
• Pediatric patients dosage: Montelukast 5 mg, 4 mg tablets, or 4 mg oral granules once daily
• No dosage adjustment is required in patients with mild-to-moderate hepatic insufficiency or renal insufficiency
• The pharmacokinetic profile and the oral bioavailability of a single 10-mg oral dose of montelukast are similar in elderly and younger adults

Interaction

• Provair has been administered with other therapies routinely used in the prophylaxis and chronic treatment of asthma with no apparent increase in adverse reactions
• Provair did not have clinically important effects on the pharmacokinetics of theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin, and warfarin
• Provair was used concomitantly with a wide range of commonly prescribed drugs in clinical studies without evidence of clinical adverse interactions
• Phenobarbital, which induces hepatic metabolism, decreased the AUC of Provair approximately 40% following a single 10mg dose of Provair

Contraindications

• Montelukast is contraindicated in patients who are hypersensitive to any component of this product

Side Effects

• Common: Diarrhoea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, upper respiratory tract infection
• Uncommon: Akathisia, anxiety, arthralgia, asthenia, abnormal behavior, depression, dizziness, drowsiness, dry mouth, haemorrhage, irritability, malaise, muscle complaints, oedema, seizure, abnormal sensation, sleep disorders
• Rare: Angioedema, concentration impaired, disorientation, eosinophilic granulomatosis with polyangiitis, erythema nodosum, hallucination, hepatic disorders, memory loss, palpitations, pulmonary eosinophilia, suicidal tendencies, tremor

Pregnancy & Lactation

• Montelukast crosses the placenta following oral dosing in rats and rabbits
• Use during pregnancy only if clearly needed and caution should be exercised when given to a nursing mother

Precautions & Warnings

• Provair is not indicated for use in the reversal of bronchospasm in acute asthma attacks
• Patients should have appropriate rescue medication available
• Provair should not be abruptly substituted for inhaled or oral corticosteroids
• Provair should not be used as monotherapy for the treatment and management of exercise induced bronchospasm
• Patients with known aspirin sensitivity should continue avoidance of aspirin or non-steroidal anti-inflammatory agents while taking Provair

Overdose Effects

• Adverse experiences in the majority of overdosage reports were consistent with the safety profile of Provair
• Usual supportive measures should be employed in the event of overdose

Therapeutic Class

• Leukotriene receptor antagonists

Storage Conditions

• Store in cool & dry place below 30°C, protect from light & moisture
• Keep out of reach of children

Chemical Structure

• Molecular Formula: C35H36ClNO3S

Common Questions about Provair 10 mg Tablet

• Provair 10 mg Tablet is a selective and orally active leukotriene receptor antagonist
• Provair 10 mg Tablet is commonly used to treat asthma or allergic rhinitis
• The effect of Provair 10 mg Tablet can be observed after 1-3 hours of administration
• The effect of Provair 10 mg Tablet lasts for an average duration of 24 hours
• Provair 10 mg Tablet may be taken with or without food as prescribed by your doctor
• Use of Provair 10 mg Tablet in pregnant women should be avoided unless clearly needed

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