Reversair 10 mg (Tablet)

Indications

• Prophylaxis and chronic treatment of asthma
• Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
• Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Pharmacology

• Selective and orally active leukotriene receptor antagonist
• Inhibition of cysteinyl leukotriene receptor (CysLT1)
• Correlation with the pathophysiology of asthma & allergic rhinitis

Dosage & Administration

• Dosage for adults and adolescents 15 years of age and older: Montelukast 10 mg tablet once daily
• Dosage for pediatric patients 6 to 14 years of age: Montelukast 5 mg tablet once daily
• Dosage for pediatric patients 2 years to 5 years of age: Montelukast 4 mg tablet once daily
• Dosage for pediatric patients 6 months to 5 years of age: Montelukast 4 mg oral granules once daily
• No dosage adjustment in patients with mild-to-moderate hepatic insufficiency
• No dosage adjustment in patients with renal insufficiency
• Similar pharmacokinetic profile and oral bioavailability in elderly and younger adults

Interaction

• No apparent increase in adverse reactions when administered with other therapies routinely used in the prophylaxis and chronic treatment of asthma
• Clinical dose did not have clinically important effects on the pharmacokinetics of specific drugs
• Used concomitantly with a wide range of commonly prescribed drugs without evidence of clinical adverse interactions

Contraindications

• Hypersensitivity to any component of this product

Side Effects

• Common: Diarrhoea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, upper respiratory tract infection
• Uncommon: Akathisia, anxiety, arthralgia, asthenia, abnormal behavior, depression, dizziness, drowsiness, dry mouth, haemorrhage, irritability, malaise, muscle complaints, oedema, seizure, abnormal sensation, sleep disorders
• Rare: Angioedema, concentration impaired, disorientation, eosinophilic granulomatosis with polyangiitis, erythema nodosum, hallucination, hepatic disorders, memory loss, palpitations, pulmonary eosinophilia, suicidal tendencies, tremor

Pregnancy & Lactation

• Crosses the placenta following oral dosing in rats and rabbits
• Use during pregnancy only if clearly needed
• Caution should be exercised when given to a nursing mother

Precautions & Warnings

• Not indicated for use in the reversal of bronchospasm in acute asthma attacks
• Appropriate rescue medication should be available
• Can be continued during acute exacerbations of asthma
• Should not be abruptly substituted for inhaled or oral corticosteroids
• Not to be used as monotherapy for the treatment and management of exercise induced bronchospasm
• Patients with known aspirin sensitivity should continue avoidance of aspirin or non-steroidal anti-inflammatory agents while taking this product

Overdose Effects

• No adverse experiences in the majority of overdosage reports
• Frequently occurring adverse experiences consistent with the safety profile of the product
• In the event of overdose, it is reasonable to employ the usual supportive measures

Therapeutic Class

• Leukotriene receptor antagonists

Storage Conditions

• Store in cool & dry place below 30°C
• Protect from light & moisture
• Keep out of reach of children

Chemical Structure

• Molecular Formula: C35H36ClNO3S
• Chemical Structure available in the provided image

Common Questions about Reversair 10 mg Tablet

• Selective and orally active leukotriene receptor antagonist
• Used to treat asthma or allergic rhinitis
• Effect can be observed after 1-3 hours of administration
• Effect lasts for an average duration of 24 hours
• May be taken with or without food as prescribed by the doctor
• Use should be avoided in pregnant women unless clearly needed

General Instructions

• Take exactly as prescribed by the doctor
• Do not change the dose without doctor's advice
• Not a fast-acting rescue medicine for asthma attacks
• Avoid situations or activities that may trigger an asthma attack
• Consult a doctor before using if pregnant or breastfeeding

Related Brands

• Reversair ODT 5 mg (Dispersible Tablet) - aci-limited
• Reversair ODT 4 mg (Dispersible Tablet) - aci-limited
• Provair 10 mg (Tablet) - unimed-unihealth-pharmaceuticals-ltd
• Provair 5 mg (Chewable Tablet) - unimed-unihealth-pharmaceuticals-ltd
• Provair 4 mg (Chewable Tablet) - unimed-unihealth-pharmaceuticals-ltd