Cenolon 40 mg/ml (IM/IA Injection)

Indications

• Short-term administration for rheumatic disorders
• Control of severe allergic conditions
• Treatment of dermatologic diseases
• Management of neoplastic diseases
• Palliative management of leukemias and lymphomas
• Treatment of respiratory diseases
• Induction of diuresis in renal diseases
• Adjunctive therapy for ophthalmic diseases
• To tide over critical period in gastrointestinal diseases
• Adjunctive therapy for nervous system diseases

Pharmacology

• White to cream-colored crystalline powder
• Practically insoluble in water
• Very soluble in alcohol
• Synthetic glucocorticoid with anti-inflammatory action
• Extended duration of effect
• Adrenal suppression occurs within 24 to 48 hours
• Returns to normal in 30 to 40 days

Dosage & Administration

• Initial dose may vary from 2.5 mg to 100 mg per day
• Recommended initial dose for systemic therapy: 60 mg
• Injection should be made deeply into the gluteal muscle
• Single local injection is frequently sufficient for intra-articular administration
• Similarly, single injections into several joints, up to a total of 80 mg, have been given

Interaction

• Aminoglutethimide may lead to loss of corticosteroid-induced adrenal suppression
• Concomitant use with amphotericin B or potassium-depleting agents may lead to hypokalemia
• Macrolide antibiotics may decrease corticosteroid clearance

Contraindications

• Hypersensitivity to any components of the product
• Contraindicated for idiopathic thrombocytopenic purpura

Side Effects

• Allergic reactions including anaphylaxis and angioedema
• Cardiovascular issues like bradycardia and hypertension
• Dermatologic reactions including acne and rash
• Endocrine issues such as glycosuria and menstrual irregularities
• Fluid and electrolyte disturbances
• Gastrointestinal issues including hepatomegaly and peptic ulcer
• Musculoskeletal problems like osteoporosis and muscle weakness
• Neurological and psychiatric effects including depression and insomnia
• Ophthalmic effects like increased intraocular pressure and cataracts

Pregnancy & Lactation

• Pregnancy Category C
• Systemically administered corticosteroids appear in human milk
• Caution should be exercised when administered to a nursing woman

Precautions & Warnings

• Steroids should be used with caution in active or latent peptic ulcers
• Intra-articularly injected corticosteroids may be systemically absorbed
• Corticosteroids decrease bone formation and increase bone resorption
• Psychic derangements may appear when corticosteroids are used
• Intraocular pressure should be monitored if steroid therapy is continued for more than 6 weeks

Use in Special Populations

• Premature and low-birth-weight infants may be more likely to develop toxicity
• No overall differences in safety or effectiveness were observed between elderly and younger subjects

Overdose Effects

• Treatment is by supportive and symptomatic therapy

Therapeutic Class

• Corticosteroid
• Glucocorticoids
• Triamcinolone & Combined preparations

Storage Conditions

• Store at controlled room temperature (20-25°C)
• Avoid freezing and protect from light

Related Brands

• Alfacort 40 mg/ml (IM/IA Injection) - ziska-pharmaceuticals-ltd