Dilarof 500 mcg (Tablet)
Unit Price: ৳ 20.00 (2 x 10: ৳ 400.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Roflumilast tablet |
| Company | Unimed unihealth pharmaceuticals ltd |
Indications
- Maintenance treatment of severe chronic obstructive pulmonary disease (COPD)
- Associated with chronic bronchitis
- Adult patients with a history of frequent exacerbations
- Add on to bronchodilator treatment
Pharmacology
- Phosphodiesterase-4 (PDE-4) inhibitor
- Potential anti-inflammatory effects in the pulmonary system
- Increased levels of intracellular cyclic AMP
- Therapeutic actions due to increased levels of cyclic AMP
Dosage & Administration
- Recommended dose of 500 micrograms Roflumilast once daily
- May need to be taken for several weeks to achieve its effect
- Studied in clinical trials for up to one year
- Swallowed with water and taken at the same time every day
- Can be taken with or without food
Interaction
- No proven cases of hazardous interactions reported
- Case report of interaction with ethanol and a compound containing pyrimethamine with dapsone
- Potentiation of betahistine with salbutamol reported
Contraindications
- Hypersensitivity to Roflumilast or its excipients
- Moderate or severe hepatic impairment
Side Effects
- Commonly reported adverse reactions include diarrhoea, weight decreased, nausea, abdominal pain, and headache
- Majority of adverse reactions were mild or moderate
- Occur within the first weeks of therapy and mostly resolve on continued treatment
- Adverse reactions ranked under the MedDRA frequency classification
Pregnancy & Lactation
- Limited data in pregnant women, with reproductive toxicity shown in animal studies
- Not recommended during pregnancy and in women of childbearing potential not using contraception
- Excretion of Roflumilast or its metabolites in milk shown in animal studies
- Roflumilast should not be used during breastfeeding
Precautions & Warnings
- Patients should be informed about the risks and precautions for safe use
- Not indicated as rescue medicinal product for the relief of acute bronchospasms
- Weight decrease may occur and should be monitored
- Not recommended in patients with certain severe diseases or using specific immunosuppressive medicinal products
Overdose Effects
- Observation of symptoms at increased rate after single oral doses of 2,500 micrograms and 5,000 micrograms
- Appropriate supportive medical care recommended in case of overdose
Therapeutic Class
- Antihistamines anti-allergies & hypo-sensitisation
Storage Conditions
- Store below 30°C
- Keep away from light and moisture
- Keep out of the reach of children