Koftex-D (10 mg+30 mg+1.25 mg)/5 ml (Syrup)

Indications

• Temporary relief of symptoms due to common cold, hay fever, or other upper respiratory allergies
• Relief of non-productive cough
• Relief of runny nose
• Relief of sneezing
• Relief of itching of the nose or throat
• Relief of itchy & watery eyes
• Relief of nasal congestion

Composition

• Dextromethorphan Hydrobromide BP 20 mg
• Phenylephrine Hydrochloride BP 10 mg
• Triprolidine Hydrochloride BP 2.5 mg

Pharmacology

• Antitussive, decongestant, and antihistamine agent
• Dextromethorphan - central action on the cough center
• Phenylephrine - decongestant that shrinks blood vessels
• Triprolidine - antihistamine with mild sedative properties

Dosage & Administration

• Adults & Children over 12 years: 1 teaspoonful (5 ml) 4 times a day every 4 hours interval
• 6-12 years: 1/2 teaspoonful 4 times a day every 4 hours interval
• Use in children and adolescents: Physician's advice required

Interaction

• Serious interaction with MAO inhibitors
• Avoid certain MAO inhibitors during treatment with this medication

Contraindications

• Avoid in patients with liver disease or asthma
• Contraindicated in patients taking monoamine oxidase inhibitors or within 2 weeks from stopping such treatment

Side Effects

• May cause drowsiness and constipation
• Other side effects: GIT discomfort

Pregnancy & Lactation

• No specific data on use during pregnancy & lactation

Precautions & Warnings

• May cause drowsiness
• Avoid driving or operating machinery
• Use caution in patients with epilepsy, prostatic hypertrophy, glaucoma, hepatic disease, etc.
• Consult a physician if symptoms do not improve within one week or are accompanied with high fever

Overdose Effects

• Respiratory depression, paranoid psychosis, hallucinations, convulsion in case of overdose

Therapeutic Class

• Combined cough suppressants

Storage Conditions

• Store in a cool and dry place below 30°C, away from light, keep out of the reach of children

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