Xerokof 15 mg/5 ml (Syrup)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ambroxol hydrochloride |
| Company | Pharmasia limited |
Indications
- Productive cough
- Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid mucus
- Inflammatory disease of rhinopharyngeal tract associated with viscid mucus
- Asthmatic bronchitis
- Bronchiectasis
- Chronic pneumonia
Pharmacology
Ambroxol is the active metabolite of bromhexine and it has greater bronchosecretolytic effect than bromhexine. It improves sputum rheology by hydrating mechanism, leading to liquefaction of mucus in the respiratory tract. It stimulates production of phospholipids of surfactant by alveolar cells, reduces bronchial hyperactivity, and has anti-inflammatory properties.
Dosage & Administration
- Pediatric Drops:
- 0-6 months: 0.5 ml 2 times a day
- 6-12 months: 1 ml 2 times a day
- 1-2 years: 1.25 ml 2 times a day
- Syrup:
- 2-5 years: 2.5 ml (1/2 teaspoonful) 2-3 times a day
- 5-10 years: 5 ml (1 teaspoonful) 2-3 times a day
- 10 years and adults: 10 ml (2 teaspoonful) 3 times a day
- Sustained release capsule: Adult and children over 12 years old: 1 capsule once daily
Interaction
Xerokof should not be taken simultaneously with antitussives (e.g. Codeine) because phlegm, which has been liquefied by Xerokof, might not be expectorated.
Contraindications
Known hypersensitivity to Ambroxol or Bromhexine
Side Effects
Gastrointestinal side effects like epigastric pain, stomach overfill feeling may occur occasionally. Rarely allergic responses such as eruption, urticaria, or angioneurotic edema have been reported.
Pregnancy & Lactation
Teratogenic and fetal toxicity studies have shown no harmful effect of Ambroxol. However, it is advised not to use it in pregnancy, especially during the 1st trimester. Safety during lactation has not been established yet.
Precautions & Warnings
Xerokof should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic and renal insufficiency should take it with caution.
Therapeutic Class
Cough expectorants & mucolytics
Storage Conditions
Protect from direct light exposure, Store in a dry place at a temperature not exceeding 30°C, Keep out of the reach of children