Cophyl (30 mg+100 mg+1.25 mg)/5 ml (Syrup)

Indications

• Symptomatic relief of upper respiratory tract disorders
• Productive cough relief
• Nasal decongestant use
• Histamine H1 receptor antagonist use
• Expectorant use

Pharmacology

• Pseudoephedrine as decongestant and bronchodilator
• Pseudoephedrine's alpha and beta adrenergic receptor agonist actions
• Pseudoephedrine's vasoconstriction mechanism
• Pseudoephedrine's bronchial relaxation mechanism
• Pseudoephedrine's norepinephrine-releasing effect
• Guaifenesin as an expectorant
• Guaifenesin's reduction of sputum viscosity
• Triprolidine as an antihistamine
• Triprolidine's symptomatic relief of hypersensitivity reactions

Dosage & Administration

• Adult dosage: 10 ml (2 teaspoonful) three times a day
• Children 6-12 years dosage: 5 ml (1 teaspoonful) three times a day
• Children 2-5 years dosage: 2.5 ml (1/2 teaspoonful) three times a day
• Prefer physician's advice for children aged less than 2 years

Interaction

• Concomitant use cautions with sympathomimetic agents
• Cautions with monoamine oxidase inhibitors
• Partial reversal of hypotensive action by sympathetic activity interfering drugs

Contraindications

• Known hypersensitivity to constituents
• Cardiovascular disease including hypertension
• Lower respiratory symptoms including asthma
• Monoamine oxidase inhibitor (MAOI) therapy

Side Effects

• CNS depression or excitation
• Drowsiness
• Sleep disturbances
• Hallucinations
• Skin rashes with or without irritation
• Tachycardia
• Dryness of mouth, nose and throat

Pregnancy & Lactation

• Caution in use during pregnancy
• Balancing potential benefits against possible hazards to the fetus

Precautions & Warnings

• Potential drowsiness
• Advice against driving or operating machinery if affected
• Cautions with alcohol or other centrally acting sedatives
• Use caution in mild to moderate hypertension patients
• Cautions in hypertension and heart disease, diabetes, hyperthyroidism patients
• Cautions in elevated intra-ocular pressure, prostatic enlargement, severe renal and hepatic impairment patients
• Not to be used for persistent or chronic cough without physician's direction

Overdose Effects

• Acute toxicity effects
• Drowsiness, irritability, restlessness, lethargy, dizziness, gastrointestinal discomfort, respiratory depression, convulsion, tremor, tachycardia, hypertension
• Necessary measures to maintain and support respiration and control convulsion in overdose
• Gastric lavage and catheterization of bladder may be necessary

Therapeutic Class

• Combined cough expectorants

Storage Conditions

• Store below 25°C
• Protect from light
• Do not refrigerate

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