Anquil 15 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Midazolam |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Short-term treatment of insomnia
- Sedation in premedication before surgical or diagnostic procedures
Description
Sleep-inducing agent with rapid onset and short duration of action; anxiolytic, anticonvulsant, and muscle-relaxant effect
Pharmacology
Mediated through inhibitory neurotransmitter GABA; increases GABA activity producing sedating effect, relaxing skeletal muscles, inducing sleep, anesthesia, and amnesia
Dosage & Administration
- Oral dosage for adults: 7.5-15 mg daily
- Oral dosage in elderly and debilitated patients: 7.5 mg
- In premedication: 15 mg 30-60 minutes before the procedure
- Intravenous administration for endoscopic or cardiovascular procedures: 2.5 mg for healthy adults
- Intravenous administration for induction of anesthesia: 10-15 mg
- Intramuscular administration for adults: 0.07-0.1 mg/kg body weight
- Rectal administration in children for preoperative sedation: 0.35-0.45 mg/kg
Interaction
Enhances central sedative effect of neuroleptics, tranquillizers, antidepressants, sleep-inducing drugs, analgesics, anesthetics, antipsychotics, anxiolytics, antiepileptic drugs, and sedative antihistamines
Contraindications
Severe respiratory/hepatic insufficiency, myasthenia gravis, sleep apnea syndrome, known hypersensitivity to benzodiazepines or any component of the product
Side Effects
Drowsiness, confusion, fatigue, headache, muscle weakness, fluctuations in vital signs, respiratory depression, apnea, variations in blood pressure, pulse rate
Pregnancy & Lactation
Avoid during pregnancy unless no safer alternative; should not be administered to breast-feeding mothers
Precautions & Warnings
Administer IV very slowly
Overdose Effects
Coma, areflexia, cardiorespiratory depression, apnea; effects can be controlled with benzodiazepine antagonist flumazenil
Therapeutic Class
- Benzodiazepine hypnotics
- Benzodiazepine sedatives
Storage Conditions
Protect from light and moisture, store in cool and dry place, keep out of reach of children