Hypnofast 7.5 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Midazolam
Company Incepta pharmaceuticals ltd
Also available as
Hypnofast 15 mg injection Hypnofast 5 mg injection Hypnofast 5 mg injection

Indications

  • Short-term treatment of insomnia
  • Sedation in premedication before surgical or diagnostic procedures

Description

Sleep-inducing agent characterized by rapid onset and short duration of action, exerts anxiolytic, anticonvulsant and muscle-relaxant effect

Pharmacology

  • Actions mediated through inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
  • Increases activity of GABA producing sedating effect, relaxing skeletal muscles, inducing sleep, anesthesia, and amnesia
  • Binds to benzodiazepine site on GABA-A receptors, potentiating effects of GABA

Dosage & Administration

  • Oral dosage for adults: 7.5-15 mg daily
  • Oral dosage in elderly and debilitated patients: The recommended dose is 7.5 mg
  • Oral dosage in premedication: 15 mg should be given 30-60 minutes before the procedure
  • Intravenous administration for endoscopic or cardiovascular procedures: In healthy adults, the initial dose is approximately 2.5 mg
  • Intravenous administration for induction of anesthesia: The dose is 10-15 mg
  • Intramuscular administration for adult: 0.07-0.1 mg/kg body weight
  • Intramuscular administration for children: 0.15-0.20 mg/kg
  • Intramuscular administration for elderly and debilitated patients: 0.025-0.05 mg/kg
  • Rectal administration in children for preoperative sedation: Rectal administration of the ampoule solution (0.35-0.45 mg/kg) 20-30 min before induction of general anesthesia

Interaction

Enhances the central sedative effect of various drugs including neuroleptics, tranquillizers, antidepressants, sleep-inducing drugs, analgesics, anesthetics, antipsychotics, anxiolytics, antiepileptic drugs and sedative antihistamines

Contraindications

Must not be given to patients with severe respiratory insufficiency, severe hepatic insufficiency, myasthenia gravis, sleep apnea syndrome and with known hypersensitivity to benzodiazepines or to any component of the product

Side Effects

  • At the start of therapy: drowsiness during daytime, confusion, fatigue, headache and muscle weakness
  • Following parenteral administration: fluctuations in vital signs including respiratory depression, apnea, variations in blood pressure and pulse rate

Pregnancy & Lactation

Should be avoided during pregnancy unless there is no safer alternative. Should not be administered to breastfeeding mothers due to passage into breast milk

Precautions & Warnings

IV administration should be very slow

Overdose Effects

Extreme overdosage may lead to coma, areflexia, cardiorespiratory depression and apnea. The effects of overdosage can be controlled with benzodiazepine antagonist flumazenil

Therapeutic Class

  • Benzodiazepine hypnotics
  • Benzodiazepine sedatives

Storage Conditions

Protect from light and moisture, store in cool and dry place, keep out of the reach of children

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