Midolam 7.5 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Midazolam |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Short-term treatment of insomnia
- Sedation in premedication before surgical or diagnostic procedures
Description
Sleep-inducing agent characterized by rapid onset and short duration of action. Exhibits anxiolytic, anticonvulsant, and muscle-relaxant effects
Pharmacology
Mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). Increases GABA activity, producing sedating effect, relaxing skeletal muscles, inducing sleep, anesthesia, and amnesia
Dosage & Administration
- Oral dosage for adults: 7.5-15 mg daily
- Oral dosage in elderly and debilitated patients: 7.5 mg
- Oral dosage for premedication: 15 mg 30-60 minutes before the procedure
- Intravenous administration dose for endoscopic or cardiovascular procedures in healthy adults: approximately 2.5 mg
- Intramuscular administration for adults: 0.07-0.1 mg/kg body weight
- Rectal administration in children for preoperative sedation: 0.35-0.45 mg/kg 20-30 min before induction of general anesthesia
Interaction
Enhances the central sedative effect of neuroleptics, tranquillizers, antidepressants, sleep-inducing drugs, analgesics, anaesthetics, antipsychotics, anxiolytics, antiepileptic drugs, and sedative antihistamines
Contraindications
Severe respiratory or hepatic insufficiency, myasthenia gravis, sleep apnea syndrome, known hypersensitivity to benzodiazepines or any component of the product
Side Effects
- Drowsiness, confusion, fatigue, headache, and muscle weakness at the start of therapy
- Parenteral administration may cause respiratory depression, apnea, variations in blood pressure, and pulse rate
Pregnancy & Lactation
Avoid during pregnancy unless no safer alternative. Avoid in breastfeeding mothers as it passes into breast milk
Precautions & Warnings
Administer IV very slowly
Overdose Effects
May lead to coma, areflexia, cardiorespiratory depression, and apnea. Can be controlled with benzodiazepine antagonist flumazenil
Therapeutic Class
- Benzodiazepine hypnotics
- Benzodiazepine sedatives
Storage Conditions
Protect from light and moisture. Store in a cool and dry place. Keep out of the reach of children