Midolam 15 mg/3 ml (IM/IV Injection)

3 ml ampoule: ৳ 75.50 (1 x 5: ৳ 377.50)

Medicine Details

Category Details
Generic Midazolam
Company Opsonin pharma ltd
Also available as
Midolam 75 mg tablet Midolam 15 mg tablet Midolam 5 mg injection

Title

Midolam

Categories

  • Insomnia Treatment
  • Sedative
  • Benzodiazepine Hypnotics
  • Benzodiazepine Sedatives

Description

Midolam is a sleep-inducing agent characterized by a rapid onset and short duration of action. It also exerts an anxiolytic, anticonvulsant, and muscle-relaxant effect.

Indications

  • Short-term treatment of insomnia
  • Sedation in premedication before surgical or diagnostic procedures

Pharmacology

Benzodiazepines like midazolam increase the activity of the inhibitory neurotransmitter GABA, producing a sedating effect, relaxing skeletal muscles, and inducing sleep, anesthesia, and amnesia.

Dosage & Administration

  • Oral:
    • For adults: 7.5-15 mg daily
    • In elderly and debilitated patients: 7.5 mg
    • In premedication: 15 mg 30-60 minutes before the procedure
  • Intravenous:
    • Endoscopic or Cardiovascular Procedures: Approximately 2.5 mg in healthy adults, 1-1.5 mg in severe illness and in elderly patients
    • Induction of Anesthesia: 10-15 mg
  • Intramuscular:
    • Adult: 0.07-0.1 mg/kg body weight, usual dose about 5 mg
    • Children: 0.15-0.20 mg/kg
    • Elderly and debilitated patients: 0.025-0.05 mg/kg
  • Rectal administration in children: Rectal administration of the ampoule solution (0.35-0.45 mg/kg) 20-30 min before induction of general anesthesia

Interaction

Enhances the sedative effect of various drugs including neuroleptics, antidepressants, analgesics, anesthetics, antiepileptics, and sedative antihistamines.

Contraindications

Severe respiratory insufficiency, severe hepatic insufficiency, myasthenia gravis, sleep apnea syndrome, and known hypersensitivity to benzodiazepines or any component of the product

Side Effects

  • Drowsiness, confusion, fatigue, headache, muscle weakness, respiratory depression, apnea, variations in blood pressure, pulse rate

Pregnancy & Lactation

Avoid during pregnancy and breastfeeding

Precautions & Warnings

Midolam IV should be administered very slowly.

Overdose Effects

May lead to coma, areflexia, cardiorespiratory depression, and apnea. Can be controlled with benzodiazepine antagonist flumazenil.

Therapeutic Class

  • Benzodiazepine hypnotics
  • Benzodiazepine sedatives

Storage Conditions

Protect from light and moisture, store in a cool and dry place. Keep out of the reach of children.

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