Milam 15 mg/3 ml (IM/IV Injection)

3 ml ampoule: ৳ 120.00

Medicine Details

Category Details
Generic Midazolam
Company Eskayef pharmaceuticals ltd
Also available as
Milam 75 mg tablet Milam 15 mg tablet

Indications

  • Short-term treatment of insomnia
  • Sedation in premedication before surgical or diagnostic procedures

Description

  • Sleep-inducing agent characterized by a rapid onset and short duration of action
  • Exerts anxiolytic, anticonvulsant, and muscle-relaxant effect

Pharmacology

  • Mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
  • Increases the activity of GABA, producing sedating effect, relaxing skeletal muscles, inducing sleep, anesthesia, and amnesia

Dosage & Administration

  • Oral dosage for adults: 7.5-15 mg daily
  • Intravenous administration for endoscopic or cardiovascular procedures: initial dose of approximately 2.5 mg for healthy adults
  • Intramuscular administration: adult dose of 0.07-0.1 mg/kg body weight
  • Rectal administration in children for preoperative sedation: 0.35-0.45 mg/kg

Interaction

  • Enhances the central sedative effect of neuroleptics, tranquillizers, antidepressants, sleep-inducing drugs, analgesics, anaesthetics, antipsychotics, anxiolytics, antiepileptic drugs, and sedative antihistamines

Contraindications

  • Severe respiratory insufficiency
  • Severe hepatic insufficiency
  • Myasthenia gravis
  • Sleep apnea syndrome
  • Known hypersensitivity to benzodiazepines or to any component of the product

Side Effects

  • Drowsiness during daytime
  • Confusion
  • Fatigue
  • Headache
  • Muscle weakness
  • Respiratory depression
  • Apnea
  • Variations in blood pressure and pulse rate

Pregnancy & Lactation

  • Avoided during pregnancy unless there is no safer alternative
  • Avoided in breastfeeding mothers due to passage into breast milk

Precautions & Warnings

  • Milam IV should be administered very slowly

Overdose Effects

  • Coma
  • Areflexia
  • Cardiorespiratory depression
  • Apnea
  • Controlled with benzodiazepine antagonist flumazenil

Therapeutic Class

  • Benzodiazepine hypnotics
  • Benzodiazepine sedatives

Storage Conditions

  • Protect from light and moisture
  • Store in cool and dry place
  • Keep out of the reach of children

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