Mizolam 7.5 mg (Tablet)
Unit Price: ৳ 8.07 (3 x 10: ৳ 242.10)
Strip Price: ৳ 80.70
Medicine Details
| Category | Details |
|---|---|
| Generic | Midazolam |
| Company | Acme laboratories ltd |
Title
- Mizolam
Categories
- Medicine
- Pharmaceutical
Description
- Sleep-inducing agent with rapid onset and short duration of action
- Anxiolytic
- Anticonvulsant
- Muscle-relaxant
Indications
- Short-term treatment of insomnia
- Sedation in premedication before surgical or diagnostic procedures
Pharmacology
- Mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)
- Increases the activity of GABA
- Produces sedating effect
- Relaxes skeletal muscles
- Induces sleep, anesthesia, and amnesia
- Binds to the benzodiazepine site on GABA-A receptors
Dosage & Administration
- Oral dosage for adults: 7.5-15 mg daily
- In premedication: 15 mg given 30-60 minutes before the procedure
- Intravenous administration for endoscopic or cardiovascular procedures: initial dose is approximately 2.5 mg in healthy adults
- Intramuscular administration for adults: 0.07-0.1 mg/kg body weight
- Rectal administration in children for preoperative sedation: 0.35-0.45 mg/kg 20-30 min before induction of general anesthesia
Interaction
- Enhances the central sedative effect of neuroleptics, tranquillizers, antidepressants, sleep-inducing drugs, analgesics, anesthetics, antipsychotics, anxiolytics, antiepileptic drugs, and sedative antihistamines
Contraindications
- Severe respiratory insufficiency
- Severe hepatic insufficiency
- Myasthenia gravis
- Sleep apnea syndrome
- Known hypersensitivity to benzodiazepines or to any component of the product
Side Effects
- Drowsiness during daytime at the start of therapy
- Confusion
- Fatigue
- Headache
- Muscle weakness
- Fluctuations in vital signs following parenteral administration including respiratory depression, apnea, variations in blood pressure, and pulse rate
Pregnancy & Lactation
- Avoided during pregnancy unless there is no safer alternative
- Passes into breast milk, should not be administered to breastfeeding mothers
Precautions & Warnings
- IV administration should be very slow
Overdose Effects
- May lead to coma, areflexia, cardiorespiratory depression, and apnea
- Can be controlled with benzodiazepine antagonist flumazenil
Therapeutic Class
- Benzodiazepine hypnotics
- Benzodiazepine sedatives
Storage Conditions
- Protect from light and moisture
- Store in cool and dry place
- Keep out of the reach of children