Epam 5 mg (Tablet)
Unit Price: ৳ 0.75 (10 x 40: ৳ 300.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Nitrazepam |
| Company | Opsonin pharma ltd |
Indications
- Short-term management of insomnia
- Infantile spasms
Pharmacology
- Benzodiazepine with sleep-inducing activity
- Depresses the reticular-activating system in the brainstem by enhancing the inhibitory effect of GABA
Dosage
- Adult: 5 mg at night; increase to 10 mg if necessary
- Elderly and debilitated patients: ≤normal adult dose
- Child: Infants: 125 mcg/kg bid; gradually increase to 250-500 mcg/kg bid
Administration
May be taken with or without food
Interaction
- CNS depressant effect increased with alcohol, barbiturates, TCAs, phenothiazines, morphine derivatives
- Effects may be antagonised by theophylline
- Increased levels/effects with probenecid
- Reduced levels/effects with rifampicin
- May reduce effects of levodopa
Contraindications
- Myasthenia gravis
- Narrow-angle glaucoma
- Severe respiratory insufficiency
- Sleep apnoea syndrome
- Severe hepatic impairment
- Porphyria
Side Effects
- Hypotension
- Palpitation
- Agitation
- Aggressiveness
- Amnesia
- Ataxia
- Confusion
- Delusions
- Disorientation
- Dizziness
- Fatigue
- Hallucination
- Hangover
- Headache
- Irritability
- Nightmares
- Psychoses
- Rage
- Restlessness
- Sedation
- Rash
- Changes in libido
- Constipation
- Diarrhoea
- Excessive salivation
- Heartburn
- Nausea
- Vomiting
- Granulocytopenia
- Leukopenia
- Falling
- Muscle weakness
- Blurred or double vision
- Tinnitus
- Associated with withdrawal
- Aspiration
- Increased bronchial secretion
- Dyspnoea
Pregnancy & Lactation
Category not classified
Precautions & Warnings
- May induce anterograde amnesia
- Caution patients to have uninterrupted sleep of 7-8 hr after ingestion of dose
- May impair ability to drive or operate machinery
- Depression, especially if suicidal risk may be present
- History of drug abuse or acute alcoholism
- Hepatic and renal impairment
- Respiratory disease
- Debilitated patients
- Patients who are at risk of falls
- Children, elderly
- Pregnancy and lactation
Overdose Effects
- Symptoms:
- Somnolence
- Drowsiness
- Confusion
- Ataxia
- Impaired reflexes
- Coma
- Dyspnoea
- Hypotension
- Respiratory and cardiovascular depression
- Management: Supportive. Gastric lavage may be beneficial if performed soon after ingestion. Flumazenil may reverse benzodiazepine-induced CNS depression
Therapeutic Class
Benzodiazepine hypnotics
Storage Conditions
Store at room temperature. Protect from light and moisture