Noctin 5 mg (Tablet)
Unit Price: ৳ 1.00 (100's pack: ৳ 100.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Nitrazepam |
| Company | Ambee pharmaceuticals ltd |
Indications
- Short-term management of insomnia
- Infantile spasms
Pharmacology
- Benzodiazepine with sleep-inducing activity
- Enhances inhibitory effect of GABA on brain cells
Dosage
- Adult dosage: 5 mg at night; increase to 10 mg if necessary
- Elderly and debilitated patients: ≤ normal adult dose
- Child dosage for infantile spasms: 125-500 mcg/kg bid
Administration
May be taken with or without food
Interaction
CNS depressant effect increased with alcohol, barbiturates, TCAs, phenothiazines, morphine derivatives. Effects may be antagonized by theophylline. Increased levels/effects with probenecid. Reduced levels/effects with rifampicin. May reduce effects of levodopa.
Contraindications
- Myasthenia gravis
- Narrow-angle glaucoma
- Severe respiratory insufficiency
- Sleep apnoea syndrome
- Severe hepatic impairment
- Porphyria
Side Effects
- Hypotension
- Amnesia
- Ataxia
- Confusion
- Dizziness
- Headache
- Rash
- Changes in libido
- Constipation
- Diarrhea
- Nausea
- Vomiting
- Leukopenia
- Muscle weakness
- Blurred or double vision
Pregnancy & Lactation
Category not classified
Precautions & Warnings
- May induce anterograde amnesia
- May impair ability to drive or operate machinery
- Depression, especially if suicidal risk may be present
- Hepatic and renal impairment
- Respiratory disease
- Children, elderly
- Pregnancy and lactation
Overdose Effects
- Symptoms:
- Somnolence
- Confusion
- Ataxia
- Respiratory and cardiovascular depression
- Management: Supportive. Gastric lavage may be beneficial if performed soon after ingestion. Flumazenil may reverse benzodiazepine-induced CNS depression.
Therapeutic Class
Benzodiazepine hypnotics
Storage Conditions
Store at room temperature. Protect from light and moisture