Azepam 5 mg (Tablet)
Unit Price: ৳ 0.69 (20 x 10: ৳ 138.00)
Strip Price: ৳ 6.90
Medicine Details
| Category | Details |
|---|---|
| Generic | Diazepam |
| Company | Acme laboratories ltd |
Title
Azepam Medicine
Categories
- Anxiolytics
- Anticonvulsants
- Tranquilizers
- Sedatives
- Muscle Relaxants
- Anti-anxiety Medication
- Anti-epileptic Drugs
Description
Azepam is a benzodiazepine derivative with anxiolytic, anticonvulsant, and central muscle relaxant actions.
Indications
- Short-term treatment of mild to moderate anxiety
- Excitation
- Agitation
- Fear
- Aggressiveness
- Anxiety reactions caused by stressed conditions
- Anxiety states with somatic expression
- Acute alcohol withdrawal
- Status epilepticus
- Premedication for surgical procedures
- Febrile convulsions
- Insomnia of hospitalized patients
Pharmacology
- Mode of Action:
- Binds to specific site on the GABA receptor
- Potentiates the effect of GABA
- Opens chloride ion channels into cells
- Absorption: Rapid and complete after oral administration
- Peak Plasma Concentration: Reached within 15-90 minutes
- Plasma Half-life: 30 hours
- Metabolism: Metabolized in the liver
- Excretion: Mainly eliminated through urine and feces
Dosage & Administration
- Oral:
- Anxiety: 2 mg thrice daily, increased if necessary to 15-30 mg daily in divided doses; Elderly or debilitated: half of the adult dose
- Insomnia associated with anxiety: 5-15 mg at bedtime
- Night terrors and somnambulism in Child: 1-5 mg at bedtime
- IM/Slow IV Injection:
- Severe acute anxiety, control of acute panic attacks, and acute alcohol withdrawal: 10 mg, repeated if necessary after not less than 4 hours
- Febrile convulsion in children: Slow IV in a dose of 250 mcg/kg
- Rectal:
- In case of children: A dose of 500 mcg/kg (maximum 10 mg), repeated if necessary
Interaction
- Contraindicated with:
- Alcohol
- Phenobarbitone
- CNS depressants
- Barbiturates
- Metabolism Inhibited by:
- Omeprazole
- Isoniazid
- Metabolism Increased by: Phenobarbitone
Side Effects
- Common Side Effects:
- Somnolence
- Dizziness
- Lightheadedness
- Higher Doses may cause:
- Confusion
- Ataxia
Contraindications
- Myasthenia gravis
- Pulmonary insufficiency
- Respiratory depression
- Hypersensitivity to benzodiazepine
Pregnancy & Lactation
Avoid during pregnancy and lactation; US FDA pregnancy category D
Precautions & Warnings
- Avoid Prolonged Use and Abrupt Withdrawal in:
- Respiratory disease
- Muscle weakness
- History of drug or alcohol abuse
- Hepatic or renal impairment
Overdose Effects
- Mild Symptoms:
- Sedation
- Muscle weakness
- Severe Symptoms:
- Ataxia
- Hypotonia
- Hypotension
- Respiratory depression
- Coma
- Death
Therapeutic Class
- Benzodiazepine sedatives
- Centrally acting Skeletal Muscle Relaxants
- Primary anti-epileptic drugs
Storage Conditions
Store in a cool (below 25°C) and dry place protected from light