Diazimet 5 mg (Tablet)
Unit Price: ৳ 0.50 (100's pack: ৳ 50.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Diazepam |
| Company | Medimet pharmaceuticals ltd |
Indications
- short-term treatment of mild to moderate anxiety
- short-term treatment of excitation and agitation
- short-term treatment of fear and aggressiveness
- anxiety reactions caused by stressed conditions
- anxiety states with somatic expression
- acute alcohol withdrawal
- status epilepticus
- premedication for surgical procedures
- febrile convulsions
- insomnia of hospitalized patients
Description
- benzodiazepine derivative
- safe tranquillizer
- anxiolytic
- anticonvulsant
- central muscle relaxant
- widely used in obstetrics
- used for control of status epilepticus
Pharmacology
- attaches to specific site on GABA receptor
- potentiates the effect of GABA
- rapid and complete absorption after oral administration
- peak plasma concentration within 15-90 minutes
- mean plasma half-life of 30 hours
- plasma protein binding of 98-99%
- metabolized in the liver
- small proportion excreted in urine
- metabolites excreted through the bile into the intestine
- eliminated with the feces
- significant absorption after rectal administration
- peak concentration within 1.5-2 hours
Dosage & Administration
- 2 mg thrice daily for anxiety
- 15-30 mg daily in divided doses for anxiety
- dose adjustment for elderly or debilitated patients
- 5-15 mg at bedtime for insomnia associated with anxiety
- 1-5 mg at bedtime for night terrors in children
- 10 mg repeated if necessary for severe acute anxiety
- 250 mcg/kg for febrile convulsion in children
- 500 mcg/kg (max 10 mg) for rectal administration in children
Interaction
- not recommended with alcohol
- increased sedation with concomitant use of neuroleptics and hypnotics
- decreased clearance with phonobarbitone
- inhibited metabolism with omeprazole and isoniazide
Contraindications
- myasthenia gravis
- pulmonary insufficiency
- respiratory depression
- hypersensitivity to benzodiazepine
Side Effects
- somnolence
- dizziness
- light headedness
- confusion
- ataxia
Pregnancy & Lactation
- crosses placental barrier
- passes into breast milk
- avoid if possible during pregnancy and lactation
- US FDA pregnancy category D
Precautions & Warnings
- prolonged use and abrupt withdrawal should be avoided
- use with caution in respiratory disease
- use with caution in muscle weakness
- use with caution in history of drug or alcohol abuse
- use with caution in hepatic or renal impairment
Overdose Effects
- sedation
- muscle weakness
- profound sleep or paradoxical excitation
- ataxia
- hypotonia
- hypotension
- respiratory depression
- rarely coma and death
Therapeutic Class
- benzodiazepine sedatives
- centrally acting skeletal muscle relaxants
- primary anti-epileptic drugs
Storage Conditions
- store in a cool place (below 25˚C)
- store in a dry place
- store protected from light