D-Pam 5 mg (Tablet)
Unit Price: ৳ 0.68 (10 x 10: ৳ 68.00)
Strip Price: ৳ 6.80
Medicine Details
| Category | Details |
|---|---|
| Generic | Diazepam |
| Company | General pharmaceuticals ltd |
Indications
- Short-term treatment of mild to moderate anxiety
- Short-term treatment of excitation
- Short-term treatment of agitation
- Short-term treatment of fear
- Short-term treatment of aggressiveness
- Treatment of anxiety reactions caused by stressed conditions
- Treatment of anxiety states with somatic expression
- Treatment of acute alcohol withdrawal
- Control of status epilepticus
- Premedication for surgical procedures
- Treatment of febrile convulsions
- Treatment of insomnia in hospitalized patients
Description
- Benzodiazepine derivative
- Safe tranquillizer
- Anxiolytic
- Anticonvulsant
- Central muscle relaxant
Pharmacology
- Attaches to specific site on the GABA receptor
- Potentiates the effect of GABA
- Opens chloride ion channels into cells
- Rapid absorption after oral administration
- Peak plasma concentration within 15-90 minutes
- Mean plasma half-life of 30 hours
- Metabolized in the liver
- 98-99% plasma protein binding
- Metabolites excreted in urine and feces
- Significant absorption after rectal administration
- Peak concentration within 1.5-2 hours
Dosage & Administration
- Oral administration
- Intramuscular administration
- Slow intravenous injection
- Rectal administration
- Different doses for anxiety, insomnia, night terrors, somnambulism, and febrile convulsion
- Varied dosing for children
Interaction
- Contraindicated with alcohol
- Increased sedation with neuroleptics, hypnotics, sedative antihistamines, and CNS depressants
- Effect on clearance with phonobarbitone and cimetidine
- Inhibition of metabolism by omeprazole and isoniazide
Contraindications
- Myasthenia gravis
- Pulmonary insufficiency
- Respiratory depression
- Hypersensitivity to benzodiazepine
Side Effects
- Somnolence
- Dizziness
- Light headedness
- Confusion
- Ataxia
Pregnancy & Lactation
- Crosses placental barrier
- Passes into breast milk
- Avoided during pregnancy and lactation
- US FDA pregnancy category D
Precautions & Warnings
- Avoid prolonged use
- Avoid abrupt withdrawal
- Caution in respiratory disease
- Caution in muscle weakness
- Caution in history of drug or alcohol abuse
- Caution in hepatic impairment
- Caution in renal impairment
Overdose Effects
- Sedation
- Muscle weakness
- Profound sleep
- Paradoxical excitation
- Ataxia
- Hypotonia
- Hypotension
- Respiratory depression
- Coma
- Death
Therapeutic Class
- Benzodiazepine sedatives
- Centrally acting skeletal muscle relaxants
- Primary anti-epileptic drugs
Storage Conditions
- Store below 25˚C temperature
- Store in a dry place
- Protected from light