Easium 10 mg (Suppository)
Unit Price: ৳ 3.01 (2 x 5: ৳ 30.10)
Medicine Details
| Category | Details |
|---|---|
| Generic | Diazepam |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Short-term treatment of mild to moderate anxiety
- Excitation
- Agitation
- Fear
- Aggressiveness
- Anxiety reactions caused by stressed conditions
- Anxiety states with somatic expression
- Acute alcohol withdrawal
- Status epilepticus
- Premedication for surgical procedures
- Febrile convulsions
- Insomnia of hospitalized patients
Description
- Benzodiazepine derivative
- Safe tranquillizer with anxiolytic, anticonvulsant, and central muscle relaxant actions
- Widely used in obstetrics and control of status epilepticus
Pharmacology
- Attaches to the specific site on the GABA receptor
- Potentiates the effect of GABA
- Rapid absorption after oral administration
- Peak plasma concentration within 15-90 minutes
- Mean plasma half-life of 30 hours
- Metabolized in the liver
- Traces of unchanged drug excreted in urine
- Metabolites excreted through the bile into the intestine and eliminated with the feces
Dosage & Administration
- Oral dosage for anxiety and insomnia
- Dosage for night terrors and somnambulism in children
- IM/slow IV injection for severe acute anxiety, control of acute panic attacks, and acute alcohol withdrawal
- Dosage for febrile convulsion in children
- Rectal dosage for children
Interaction
- Contraindicated with alcohol
- Potential interaction with neuroleptics, hypnotics, sedative antihistamines, CNS depressants, general anesthetics, narcotic analgesics, antidepressants, phonobarbitone, cimetidine, omeprazole, and isoniazide
Contraindications
- Myasthenia gravis
- Pulmonary insufficiency
- Respiratory depression
- Hypersensitivity to benzodiazepine
Side Effects
- Somnolence
- Dizziness
- Lightheadedness
- Confusion
- Ataxia
Pregnancy & Lactation
- Crosses the placental barrier
- Passes into breast milk
- Avoidance during pregnancy and lactation
- US FDA pregnancy category D
Precautions & Warnings
- Avoid prolonged use and abrupt withdrawal
- Caution in respiratory disease
- Caution in muscle weakness
- Caution in history of drug or alcohol abuse
- Caution in hepatic or renal impairment
Overdose Effects
- Sedation
- Muscle weakness
- Profound sleep
- Paradoxical excitation
- Ataxia
- Hypotonia
- Hypotension
- Respiratory depression
- Coma
- Death
Therapeutic Class
- Benzodiazepine sedatives
- Centrally acting Skeletal Muscle Relaxants
- Primary anti-epileptic drugs
Storage Conditions
- Store in a cool and dry place
- Protected from light