G-Diazepam 5 mg (Tablet)
Unit Price: ৳ 0.50 (10 x 10: ৳ 50.00)
Strip Price: ৳ 5.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Diazepam |
| Company | Gonoshasthaya pharma ltd |
| Also available as |
Indications
- Short-term treatment of anxiety
- Treatment of excitation and agitation
- Management of fear and aggressiveness
- Addressing anxiety reactions caused by stressed conditions
- Treatment of anxiety states with somatic expression
- Management of acute alcohol withdrawal
- Control of status epilepticus
- Premedication for surgical procedures
- Management of febrile convulsions
- Treatment of insomnia in hospitalized patients
Description
- Benzodiazepine derivative
- Safe tranquillizer
- Anxiolytic
- Anticonvulsant
- Central muscle relaxant actions
- Widely used in obstetrics
- Available in intravenous form
Pharmacology
- Attaches to specific site on GABA receptor
- Potentiates the effect of GABA
- Opens chloride ion channels into cells
- Rapid and complete absorption after oral administration
- Peak plasma concentration within 15-90 minutes
- Mean plasma half-life of 30 hours
- 98-99% plasma protein binding
- Metabolized in the liver
- Traces of unchanged drug excreted in urine
- Metabolites excreted through bile into intestine
- Eliminated with the feces
- Rectal administration in suppository form
Dosage & Administration
- Oral administration for anxiety, insomnia, and in children
- IM/slow IV injection for severe acute anxiety and febrile convulsion in children
- Rectal administration for children
- Specific dosage recommendations for different conditions
Interaction
- Contraindicated with alcohol
- Increased sedation with concomitant use of neuroleptics, hypnotics, and CNS depressants
- Enhanced clearance with phonobarbitone
- Decreased clearance with cimetidine
- Inhibition of metabolism by omeprazole and isoniazide
Contraindications
- Myasthenia gravis
- Pulmonary insufficiency
- Respiratory depression
- Hypersensitivity to benzodiazepine
Side Effects
- Somnolence
- Dizziness
- Light headedness
- Confusion
- Ataxia
- Dose-dependent occurrence
- Generally well tolerated at normal doses
Pregnancy & Lactation
- Crosses placental barrier
- Passes into breast milk
- Avoided during pregnancy and lactation
- US FDA pregnancy category D
Precautions & Warnings
- Prolonged use and abrupt withdrawal should be avoided
- Caution in respiratory disease and muscle weakness
- Caution in history of drug or alcohol abuse
- Caution in hepatic or renal impairment
Overdose Effects
- Sedation
- Muscle weakness
- Profound sleep
- Paradoxical excitation
- Ataxia
- Hypotonia
- Hypotension
- Respiratory depression
- Rarely coma and death
Therapeutic Class
- Benzodiazepine sedatives
- Centrally acting Skeletal Muscle Relaxants
- Primary anti-epileptic drugs
Storage Conditions
- Store in cool (below 25˚C) and dry place
- Protected from light