G-Diazepam 10 mg/2 ml (IM/IV Injection)
2 ml ampoule: ৳ 7.00 (2 x 5: ৳ 70.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Diazepam |
| Company | Gonoshasthaya pharma ltd |
| Also available as |
Title
- G-G-Diazepam
Categories
- Benzodiazepine
- Tranquilizer
- Anxiolytic
- Anticonvulsant
- Muscle Relaxant
- Sedative
- Antiepileptic Drug
- Suppository
- Oral Medication
- Injection
- Central Nervous System Medication
Description
- Benzodiazepine derivative
- Safe tranquillizer
- Anxiolytic action
- Anticonvulsant action
- Muscle relaxant action
- Widely used in obstetrics
- Control of status epilepticus
Indications
- Mild to moderate anxiety
- Excitation
- Agitation
- Fear
- Aggressiveness
- Anxiety reactions caused by stressed conditions
- Anxiety states with somatic expression
- Acute alcohol withdrawal
- Status epilepticus
- Premedication for surgical procedures
- Febrile convulsions
- Insomnia of hospitalized patients
Pharmacology
- Attaches to GABA receptor
- Potentiates effect of GABA
- Opens chloride ion channels into cells
- Rapid and complete absorption after oral administration
- Peak plasma concentration within 15-90 minutes
- Mean plasma half-life of 30 hours
- 98-99% plasma protein binding
- Metabolized in the liver
- Traces excreted in urine
- Metabolites excreted through bile into intestine
- Eliminated with feces
- Significant absorption after rectal administration
- Peak concentration within 1.5-2 hours
Dosage and Administration
- Oral administration for anxiety
- Increased dosage if necessary
- Different doses for insomnia and night terrors
- IM/slow IV injection for severe acute anxiety and febrile convulsions in children
- Rectal administration for children
- Dosage adjustments for elderly or debilitated patients
Interaction
- Contraindication with alcohol
- Increased sedation with concomitant use of neuroleptics, hypnotics, sedative antihistamines, and CNS depressants
- G-G-Diazepam clearance affected by concomitant administration of phonobarbitone and cimetidine
- Inhibition of metabolism by omeprazole and isoniazide
Contraindications
- Myasthenia gravis
- Pulmonary insufficiency
- Respiratory depression
- Hypersensitivity to bezodiazepine
Side Effects
- Somnolence
- Dizziness
- Lightheadedness
- Confusion
- Ataxia
Pregnancy and Lactation
- Crosses placental barrier
- Passes into breast milk
- Avoid during pregnancy and lactation
- US FDA pregnancy category D
Precautions and Warnings
- Prolonged use should be avoided
- Caution in respiratory disease
- Caution in muscle weakness
- Caution in history of drug or alcohol abuse
- Caution in hepatic or renal impairment
Overdose Effects
- Sedation
- Muscle weakness
- Profound sleep
- Paradoxical excitation
- Ataxia
- Hypotonia
- Hypotension
- Respiratory depression
- Coma
- Death
Therapeutic Class
- Benzodiazepine sedatives
- Centrally acting skeletal muscle relaxants
- Primary anti-epileptic drugs
Storage Conditions
- Store below 25˚C temperature
- Cool and dry place
- Protected from light