Pharmapam 5 mg (Tablet)
Unit Price: ৳ 0.25 (250's pack: ৳ 62.50)
Medicine Details
| Category | Details |
|---|---|
| Generic | Diazepam |
| Company | Pharmadesh laboratories ltd |
Title
- Pharmapam
Categories
- Anxiety medication
- Tranquilizer
- Anticonvulsant
- Muscle relaxant
Indications
- Short-term treatment of mild to moderate anxiety
- Excitation
- Agitation
- Fear
- Aggressiveness
- Anxiety states with somatic expression
- Acute alcohol withdrawal
- Status epilepticus
- Premedication for surgical procedures
- Febrile convulsions
- Insomnia of hospitalized patients
Description
- Benzodiazepine derivative
- Safe tranquillizer
- Anxiolytic
- Central muscle relaxant
- Intravenous injection widely used in obstetrics and control of status epilepticus
Mode of Action
- Attaches to specific site on the GABA receptor
- Potentiates the effect of GABA
- Opens chloride ion channels into cells
- Rapid and complete absorption after oral administration
- Metabolized in the liver
- Peak plasma concentration reaches within 15-90 minutes
- Mean plasma half-life is 30 hours
- Plasma protein binding is 98-99%
- Small proportion of metabolites excreted through bile into the intestine and eliminated with the feces
Dosage and Administration
- Oral administration for anxiety, insomnia associated with anxiety, and night terrors in children
- IM/slow IV injection for severe acute anxiety, control of panic attacks, acute alcohol withdrawal, and febrile convulsion in children
- Rectal administration for children
Interaction
- Contraindicated with alcohol
- Increased sedation with concomitant use of neuroleptics, hypnotics, sedative antihistamines, and CNS depressants
- Pharmapam clearance increased by phonobarbitone and decreased by cimetidine
- Inhibition of Pharmapam metabolism by omeprazole and isoniazide
Contraindications
- Myasthenia gravis
- Pulmonary insufficiency
- Respiratory depression
- Hypersensitivity to benzodiazepine
Side Effects
- Somnolence
- Dizziness
- Lightheadedness
- Confusion
- Ataxia
Pregnancy and Lactation
- Crosses placental barrier
- Passes into breast milk
- Avoid if possible during pregnancy and lactation
- US FDA pregnancy category D
Precautions and Warnings
- Avoid prolonged use and abrupt withdrawal
- Caution in respiratory disease
- Muscle weakness
- History of drug or alcohol abuse
- Hepatic or renal impairment
Overdose Effects
- Sedation
- Muscle weakness
- Profound sleep or paradoxical excitation
- Ataxia
- Hypotonia
- Hypotension
- Respiratory depression
- Rarely coma and death
Therapeutic Class
- Benzodiazepine sedatives
- Centrally acting Skeletal Muscle Relaxants
- Primary anti-epileptic drugs
Storage Conditions
- Store in a cool and dry place below 25°C