Relaxen 5 mg (Tablet)
Unit Price: ৳ 0.68 (100's pack: ৳ 68.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Diazepam |
| Company | Sonear laboratories ltd |
Indications
- Mild to moderate anxiety treatment
- Excitation treatment
- Agitation treatment
- Fear treatment
- Aggressiveness treatment
- Anxiety reactions treatment
- Anxiety states with somatic expression treatment
- Acute alcohol withdrawal treatment
- Status epilepticus treatment
- Premedication for surgical procedures
- Febrile convulsions treatment
- Insomnia treatment
Description
- Benzodiazepine derivative
- Safe tranquillizer
- Anxiolytic action
- Anticonvulsant action
- Central muscle relaxant action
- Widely used in obstetrics
- Control of status epilepticus
Pharmacology
- Attaches to specific site on GABA receptor
- Potentiates effect of GABA
- Opens chloride ion channels into cells
- Rapid and complete absorption after oral administration
- Peak plasma concentration in 15-90 minutes
- Mean plasma half-life of 30 hours
- Metabolized in the liver
- Traces of unchanged drug excreted in urine
- Metabolites excreted through bile into the intestine
- Eliminated with the feces
- Significant absorption after rectal administration
- Peak concentration within 1.5-2 hours
Dosage & Administration
- Oral administration for anxiety
- Oral administration for insomnia associated with anxiety
- Oral administration for night terrors and somnambulism in children
- IM/slow IV injection for severe acute anxiety and acute alcohol withdrawal
- IM/slow IV injection for febrile convulsion in children
- Rectal administration in case of children
Interaction
- Concomitant intake with alcohol not recommended
- Increased sedation due to concomitant use of neuroleptics, hypnotics, sedative antihistamines, and CNS depressants
- Relaxen clearance increased by concomitant administration of phenobarbitone
- Relaxen clearance decreased by administration of cimetidine
- Inhibition of Relaxen metabolism by omeprazole and isoniazid
Contraindications
- Myasthenia gravis
- Pulmonary insufficiency
- Respiratory depression
- Hypersensitivity to benzodiazepine
Side Effects
- Somnolence
- Dizziness
- Light headedness
- Confusion
- Ataxia
Pregnancy & Lactation
- Crosses the placental barrier
- Passes into breast milk
- Should be avoided during pregnancy
- Should be avoided during lactation
- US FDA pregnancy category D
Precautions & Warnings
- Prolonged use should be avoided
- Abrupt withdrawal should be avoided
- Use with caution in respiratory disease
- Use with caution in muscle weakness
- Use with caution in history of drug or alcohol abuse
- Use with caution in hepatic impairment
- Use with caution in renal impairment
Overdose Effects
- Sedation
- Muscle weakness
- Profound sleep or paradoxical excitation
- Ataxia
- Hypotonia
- Hypotension
- Respiratory depression
- Coma
- Death
Therapeutic Class
- Benzodiazepine sedatives
- Centrally acting skeletal muscle relaxants
- Primary anti-epileptic drugs
Storage Conditions
- Store in cool place (below 25˚C)
- Store in dry place
- Protect from light