Sedatab 5 mg (Tablet)
Unit Price: ৳ 0.68 (100's pack: ৳ 68.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Diazepam |
| Company | Supreme pharmaceutical ltd |
Indications
- Short-term treatment of anxiety
- Treatment of excitation
- Treatment of agitation
- Treatment of fear
- Treatment of aggressiveness
- Treatment of anxiety reactions caused by stress
- Treatment of anxiety states with somatic expression
- Treatment of acute alcohol withdrawal
- Premedication for surgical procedures
- Treatment of febrile convulsions
- Treatment of insomnia in hospitalized patients
Description
- Benzodiazepine derivative
- Safe tranquillizer
- Anxiolytic
- Anticonvulsant
- Central muscle relaxant
- Widely used in obstetrics
- Used for control of status epilepticus
Pharmacology
- Attaches to specific site on GABA receptor
- Potentiates effect of GABA
- Opens chloride ion channels into cells
- Rapid and complete absorption after oral administration
- Peak plasma concentration within 15-90 minutes
- Mean plasma half-life of 30 hours
- 98-99% plasma protein binding
- Metabolized in the liver
- Only traces of unchanged drug excreted in urine
- Small proportion of metabolites excreted through bile into intestine
Dosage & Administration
- Oral dosage for anxiety
- Oral dosage for insomnia associated with anxiety
- Oral dosage for night terrors and somnambulism in children
- IM/slow IV injection dosage for severe acute anxiety
- IM/slow IV injection for febrile convulsions in children
- Rectal dosage for children
Interaction
- Concomitant intake with alcohol not recommended
- Increased sedation due to concomitant use of neuroleptics
- Increased sedation due to concomitant use of hypnotics
- Increased sedation due to concomitant use of sedative antihistamines
- Increased sedation due to concomitant use of CNS depressants
- Increased clearance with concomitant administration of phonobarbitone
- Decreased clearance with concomitant administration of cimetidine
- Inhibition of metabolism by omeprazole
- Inhibition of metabolism by isoniazid
Contraindications
- Contraindicated in myasthenia gravis
- Contraindicated in pulmonary insufficiency
- Contraindicated in respiratory depression
- Contraindicated in hypersensitivity to benzodiazepine
Side Effects
- Somnolence
- Dizziness
- Lightheadedness
- Confusion
- Ataxia
Pregnancy & Lactation
- Crosses placental barrier
- Passes into breast milk
- Avoid if possible during pregnancy
- Avoid if possible during lactation
- US FDA pregnancy category D
Precautions & Warnings
- Prolonged use should be avoided
- Abrupt withdrawal should be avoided
- Use with caution in respiratory disease
- Use with caution in muscle weakness
- Use with caution in history of drug or alcohol abuse
- Use with caution in hepatic impairment
- Use with caution in renal impairment
Overdose Effects
- Sedation
- Muscle weakness
- Profound sleep
- Paradoxical excitation
- Ataxia
- Hypotonia
- Hypotension
- Respiratory depression
- Coma
- Death
Therapeutic Class
- Benzodiazepine sedatives
- Centrally acting skeletal muscle relaxants
- Primary anti-epileptic drugs
Storage Conditions
- Store below 25°C
- Store in a cool and dry place
- Protect from light