Sedil 5 mg (Tablet)
Unit Price: ৳ 0.69 (25 x 20: ৳ 345.00)
Strip Price: ৳ 13.80
Medicine Details
| Category | Details |
|---|---|
| Generic | Diazepam |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Short-term treatment of mild to moderate anxiety
- Excitation
- Agitation
- Fear
- Aggressiveness
- Anxiety reactions caused by stressed conditions
- Anxiety states with somatic expression
- Acute alcohol withdrawal
- Status epilepticus
- Premedication for surgical procedures
- Febrile convulsions
- Insomnia of hospitalized patients
Description
- Safe tranquillizer
- Anxiolytic
- Anticonvulsant
- Central muscle relaxant actions
- Intravenous injection widely used in obstetrics control of status epilepticus
Pharmacology
- Attaches to specific site on GABA receptor
- Potentiates the effect of GABA
- Rapid and complete absorption after oral administration
- Peak plasma concentration within 15-90 minutes
- Mean plasma half-life of 30 hours
- Metabolized in the liver
- Metabolites excreted in urine and through the bile into the intestine
- Eliminated with the feces
- Significantly absorbed after rectal administration
- Peak concentration reaches within 1.5-2 hours
Dosage & Administration
- Oral administration for anxiety, insomnia, night terrors, and somnambulism
- IM/slow IV injection for severe acute anxiety, acute panic attacks, acute alcohol withdrawal, and febrile convulsion in children
- Rectal administration for children
- Different doses for specific conditions
Interaction
- Contraindicated with alcohol
- Increased sedation with concomitant use of neuroleptics, hypnotics, sedative antihistamines, and CNS depressants
- Clearance increased by concomitant administration of phenobarbitone
- Clearance decreased by administration of cimetidine
- Inhibition of metabolism by omeprazole and isoniazide
Contraindications
- Myasthenia gravis
- Pulmonary insufficiency
- Respiratory depression
- Hypersensitivity to benzodiazepine
Side Effects
- Somnolence
- Dizziness
- Lightheadedness
- Confusion
- Ataxia
Pregnancy & Lactation
- Crosses placental barrier
- Passes into breast milk
- Avoid if possible during pregnancy and lactation
- US FDA pregnancy category D
Precautions & Warnings
- Avoid prolonged use
- Avoid abrupt withdrawal
- Use with caution in respiratory disease
- Use with caution in muscle weakness
- Use with caution in history of drug or alcohol abuse
- Use with caution in hepatic or renal impairment
Overdose Effects
- Sedation
- Muscle weakness
- Profound sleep
- Paradoxical excitation
- Ataxia
- Hypotonia
- Hypotension
- Respiratory depression
- Rarely coma and death
Therapeutic Class
- Benzodiazepine sedatives
- Centrally acting skeletal muscle relaxants
- Primary anti-epileptic drugs
Storage Conditions
- Store in cool and dry place
- Protect from light