Seequil-S 5 mg (Tablet)
Unit Price: ৳ 0.21 (100's pack: ৳ 21.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Diazepam |
| Company | Seema pharmaceuticals ltd |
Indications
- Short-term treatment of mild to moderate anxiety
- Excitation relief
- Agitation alleviation
- Fear management
- Aggressiveness control
- Anxiety reactions caused by stressed conditions
- Anxiety states with somatic expression
- Acute alcohol withdrawal relief
- Control of status epilepticus
- Premedication for surgical procedures
- Febrile convulsions management
- Insomnia treatment for hospitalized patients
Description
- Benzodiazepine derivative
- Safe tranquillizer
- Anxiolytic
- Anticonvulsant
- Central muscle relaxant
- Widely used in obstetrics
- Used for control of status epilepticus
Pharmacology
- Attaches to specific site on the GABA receptor
- Potentiates the effect of GABA
- Opens chloride ion channels into cells
- Rapid and complete absorption after oral administration
- Peak plasma concentration within 15-90 minutes
- Mean plasma half-life of 30 hours
- 98-99% plasma protein binding
- Metabolized in the liver
- Traces of unchanged drug excreted in urine
- Metabolites excreted through the bile into the intestine
- Eliminated with the feces
- Significantly absorbed after rectal administration in suppository form
- Peak concentration reaches within 1.5-2 hours
Dosage & Administration
- Oral administration for anxiety relief
- Oral dosage 2 mg thrice daily
- Increased dosage to 15-30 mg daily if necessary
- Elderly or debilitated patients to receive half of the adult dose
- Insomnia treatment dosage 5-15 mg at bedtime
- Night terrors and somnambulism treatment dosage 1-5 mg at bedtime
- IM/slow IV injection for severe acute anxiety
- Control of acute panic attacks with IM/slow IV injection
- Large vein, rate below 5 mg/minute for slow IV injection
- Dosage for febrile convulsion in children
- Rectal administration in case of children
- Rectal dosage of 500 mcg/kg (maximum 10 mg)
Interaction
- Concomitant intake with alcohol not recommended
- Increased sedation due to concomitant use of neuroleptics, hypnotics, sedative antihistamines, and CNS depressants
- Seequil-S clearance increased by concomitant administration of phonobarbitone
- Seequil-S clearance decreased by administration of cimetidine
- Inhibition of Seequil-S metabolism by omeprazole and isoniazide
Contraindications
- Myasthenia gravis
- Pulmonary insufficiency
- Respiratory depression
- Hypersensitivity to benzodiazepine
Side Effects
- Somnolence at higher doses
- Dizziness
- Light headedness
- Confusion
- Ataxia
Pregnancy & Lactation
- Crosses placental barrier
- Passes into breast milk
- Avoidable during pregnancy and lactation
- US FDA pregnancy category D
Precautions & Warnings
- Prolonged use should be avoided
- Abrupt withdrawal should be avoided
- Caution in respiratory disease
- Caution in muscle weakness
- Caution in history of drug or alcohol abuse
- Caution in hepatic impairment
- Caution in renal impairment
Overdose Effects
- Sedation
- Muscle weakness
- Profound sleep
- Paradoxical excitation
- Ataxia
- Hypotonia
- Hypotension
- Respiratory depression
- Coma
- Death
Therapeutic Class
- Benzodiazepine sedatives
- Centrally acting skeletal muscle relaxants
- Primary anti-epileptic drugs
Storage Conditions
- Store in a cool place
- Store below 25°C temperature
- Store in a dry place
- Protect from light