Alfumax ER 10 mg (Tablet (Extended Release))

Indications

• Treatment of benign prostatic hyperplasia (BPH)
• Treatment of lower urinary tract symptoms (LUTS)
• Relief of urinary frequency
• Relief of nocturia
• Relief of incomplete emptying
• Relief of urinary hesitancy

Pharmacology

• Selective antagonist of post-synaptic a1 adrenoreceptors
• Relaxes tone of prostate smooth muscle
• Relaxes prostate capsule
• Relaxes bladder neck
• Relaxes proximal urethra
• Binds competitively and selectively to post synaptic a1-adrenergic receptors

Dosage

• Recommended dose of 10 mg once daily after a meal for BPH
• Recommended dose of 10 mg daily after a meal for acute urinary retention (AUR) in patients 65 years and older

Administration

• Tablet should be swallowed whole

Interaction

• Contraindicated with alpha-1-receptor blockers
• To be cautious with antihypertensive drugs
• To be cautious with nitrates
• Potent CYP3A4 inhibitors to be taken into account

Contraindications

• Use with caution in patients with acute cardiac failure
• Caution in patients with hypersensitivity to alpha-1-blockers
• Caution in patients with congenital or acquired QTc prolongation
• Not recommended for patients with severe renal impairment
• Avoid other modes of administration such as crushing or grinding
• Inform ophthalmologists of past use of alpha-1-blockers before cataract surgery

Side Effects

• Common: faintness/dizziness, headache
• Uncommon: syncope, vertigo, malaise, drowsiness
• Uncommon: vision abnormal
• Uncommon: tachycardia, palpitations
• Uncommon: hypotension (postural)
• Common: nausea, abdominal pain
• Uncommon: diarrhoea, dry mouth, vomiting
• Uncommon: rash, pruritus
• Common: asthenia, flushes, chest pain

Pregnancy & Lactation

• Not applicable due to indication

Precautions & Warnings

• Withdraw tablets before general anesthesia
• Discontinue if symptoms of angina pectoris start or worsen

Use in Special Populations

• Not indicated for use in the pediatric population (2 to 16 years)

Overdose Effects

• Hospitalization may be necessary
• Supine position for the patient
• Conventional treatment of hypotension
• Corrective treatment may be vasoconstrictor

Therapeutic Class

• BPH/ Urinary retention/ Urinary incontinence

Storage Conditions

• Store in a cool and dry place, protected from light

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