Ebazam 10 mg (Tablet)

Unit Price: ৳ 3.00 (100's pack: ৳ 300.00)

Medicine Details

Category Details
Generic Clobazam
Company Edruc limited

Title and Categories

  • Ebazam Tablets
  • Anxiolytic
  • Antiepileptic
  • Benzodiazepine Hypnotics

Dimensions

5 mm diameter

Color Options

  • White
  • Off-white

Functions

  • Anxiety relief
  • Epilepsy management
  • Central nervous system depressant

Dosage

  • General Dosage: Adjusted to indication, severity of condition, and clinical response
  • Treatment of Anxiety States:
    • Adults and Adolescents over 15 years:
      • Initial dose: 20 mg daily
      • Maximum daily dose: 30 mg
    • Elderly: Maintenance dose of 10 to 15 mg daily
    • Children from 3 to 15 years: Daily dose of 5 to 10 mg
  • Treatment of Epilepsy:
    • Adults and Adolescents over 15 years: Administer at small doses, gradually increase to a maximum daily dose of about 80 mg

Administration

  • Administer whole or crushed and mixed in applesauce
  • 10 mg tablets are divisible into equal halves of 5 mg
  • Can be taken with or without food

Pharmacology

Binds to distinct binding sites at GABA receptors, enhancing the inhibitory effect of GABA

Interaction

  • Alcohol
  • Central nervous system depressant drugs
  • Opioids
  • Anticonvulsants
  • Narcotic analgesics
  • Muscle relaxants
  • CYP 2C19 inhibitors
  • CYP 2D6 substrates

Contraindications

  • Hypersensitivity to clobazam or any excipients
  • Myasthenia gravis
  • Severe respiratory insufficiency
  • Sleep apnoea syndrome
  • Severe impairment of liver function
  • Breastfeeding
  • Children between 6 months and 3 years

Side Effects

  • Metabolism and Nutrition Disorders:
    • Decreased appetite
  • Psychiatric Disorders:
    • Irritability
    • Aggression
    • Restlessness
    • Depression
    • Agitation
  • Nervous System Disorders:
    • Somnolence
    • Sedation
    • Dizziness
    • Headache
  • Eye Disorders: Diplopia
  • Respiratory, Thoracic and Mediastinal Disorders: Respiratory depression
  • Gastrointestinal Disorders:
    • Dry mouth
    • Nausea
    • Constipation
  • Skin and Subcutaneous Disorders:
    • Rash
    • Photosensitivity reaction
  • Musculoskeletal and Connective Tissue Disorders:
    • Muscle spasms
    • Muscle weakness
  • General Disorders and Administration Site Conditions:
    • Fatigue
    • Hypothermia
  • Investigations: Increased weight

Pregnancy & Lactation

  • Pregnancy:
    • Not recommended in first trimester
    • Potential risk to fetus
    • Neonatal respiratory depression
    • Physical dependence in newborns
  • Lactation: Not recommended

Precautions & Warnings

  • Serious Skin Reactions: Reported cases of Stevens-Johnson syndrome and toxic epidermal necrolysis
  • Respiratory Depression: Possible especially in high doses
  • Muscle Weakness: Can cause muscle weakness
  • Renal and Hepatic Impairment: Increased susceptibility to adverse effects
  • Elderly Patients: Increased risk of fall and serious injury
  • Tolerance in Epilepsy: Consideration for decrease in anticonvulsant efficacy
  • CYP2C19 Poor Metabolizers: Expected increase in active metabolite levels
  • Suicidality: Increased incidence of suicidal behavior in certain patients
  • Concomitant use of CYP2C19 inhibitors: Possible increased adverse effects

Therapeutic Class

Benzodiazepine hypnotics

Storage Conditions

Store below 30°C and protect from light

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