Frisium 10 mg (Tablet)
Unit Price: ৳ 5.02 (10 x 10: ৳ 502.00)
Strip Price: ৳ 50.20
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobazam |
| Company | Synovia pharma plc |
Title
Categories
Description
Indications
- Treatment of acute and chronic anxiety states
- Management of symptoms like anxiety, tension, restlessness
- Relief from psychovegetative and psychosomatic disorders
- Adjunctive therapy in epilepsy
- Concomitant treatment of anxiety associated with depression
Pharmacology
- Binds at distinct binding sites associated with the chloride ionopore at the post-synaptic GABA receptor
- Increases the duration of time for which the chloride ionopore is open
- Enhances post-synaptic inhibitory effect of GABA
Dosage
- Adjusted based on indication and severity of the condition
- Initial dose for adults and adolescents
- Initial dose for children from 3 to 15 years of age
- Secondary dosage adjustment after symptom improvement
- Timing of doses recommendations
- Duration of treatment guidelines
- Discontinuation of treatment recommendations
Administration
- Administration as whole tablets or crushed and mixed in applesauce
- Divisibility of 10 mg tablets
- Administration with or without food
Interaction
- Effects of alcohol consumption
- Potential interactions with central nervous system depressant drugs
- Risks associated with concomitant use of opioids
- Interactions with anticonvulsants
- Enhancement of effects with narcotic analgesics and muscle relaxants
- Inhibitory effects of CYP2C19 inhibitors
- Weak CYP2D6 inhibition
Contraindications
- Hypersensitivity to clobazam or any excipients
- Myasthenia gravis
- Severe respiratory insufficiency
- Sleep apnoea syndrome
- Severe impairment of liver function
- Breastfeeding
- Children between 6 months and 3 years
Side Effects
- Metabolism and nutrition disorders
- Psychiatric disorders
- Nervous system disorders
- Eye Disorders
- Respiratory, thoracic and mediastinal disorders
- Gastrointestinal disorders
- Skin and subcutaneous disorders
- Musculoskeletal and connective tissue disorders
- General disorders and administration site conditions
Pregnancy & Lactation
- Recommended avoidance during first trimester of pregnancy
- Use during pregnancy justifies potential risk to the fetus
- Cautions regarding breastfeeding women
- Potential risk of reduced fetal movement and respiratory depression in newborns
Precautions & Warnings
- Serious skin reactions
- Risk of respiratory depression
- Potential for muscle weakness
- Increased susceptibility in patients with renal and hepatic impairment
- Higher sensitivity in elderly patients
- Potential tolerance development in epilepsy treatment
- Considerations for CYP2C19 poor metabolizers
- Increased risk of suicidality
- Concomitant use of CYP2C19 inhibitors
Therapeutic Class
- Benzodiazepine hypnotics
Storage Conditions
- Expiry date and storage temperature
- Protection from light
- Keeping out of reach of children