Nebium 10 mg (Tablet)
Unit Price: ৳ 2.55 (10 x 10: ৳ 255.00)
Strip Price: ৳ 25.50
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobazam |
| Company | Globe pharmaceuticals ltd |
Indications
- Acute anxiety relief
- Chronic anxiety relief
- Restlessness relief
- Emotional instability relief
- Cardiovascular disorder relief
- Gastrointestinal disorder relief
- Sleep disturbances relief
- Psychovegetative disorders relief
- Psychosomatic disorders relief
- Adjunctive therapy for depression
- Adjunctive therapy for schizophrenia
- Adjunctive therapy for epilepsy
Pharmacology
- Binds to chloride ionopore
- Increases GABA receptor activity
- Hyperpolarization induction
- Membrane stabilization
Dosage
- Adjustment based on indication
- Dosage tailored to severity
- Individual clinical response consideration
- Minimizing interference with alertness
- Initial dosage of 20mg for adults and adolescents over 15 years
- Increased responsiveness in elderly
- Low initial doses for children
- Secondary dosage adjustment
- Duration as short as possible
- Reassessment after a maximum of 4 weeks
- Duration not to exceed 8-12 weeks
- Gradual discontinuation recommended
Administration
- Can be administered whole or crushed
- Can be mixed with applesauce
- Can be taken with or without food
- 10mg tablets can be divided into two
- Larger portion recommended in the evening
Interaction
- Increased bioavailability with alcohol
- Mutually potentiating effect with CNS depressants
- Increased risk when concomitant use with opioids
- Dosage adjustment with anticonvulsants
- Possible enhanced euphoria with narcotic analgesics
- Enhanced effects with muscle relaxants
- Potential interactions with CYP inhibitors
- Weak CYP2D6 inhibition
Contraindications
- Hypersensitivity to clobazam or excipients
- Myasthenia gravis
- Severe respiratory insufficiency
- Sleep apnea syndrome
- Severe impairment of liver function
- Breastfeeding
- Children between 6 months and 3 years
Side Effects
- Decreased appetite
- Irritability
- Aggression
- Restlessness
- Sedation
- Dizziness
- Respiratory depression
- Dry mouth
- Nausea
- Rash
- Muscle spasms
- Fatigue
- Weight increase
Pregnancy & Lactation
- Not recommended during 1st trimester
- Potential risks to fetus
- Crosses placenta
- Possible malformations
- Potential neonatal respiratory depression
- Physical dependence in newborns
- Not recommended during breastfeeding
Precautions & Warnings
- Serious skin reactions monitoring
- Respiratory function monitoring
- Muscle weakness caution
- Renal and hepatic function checking
- Elderly patient sensitivity
- Possible decrease in anticonvulsant efficacy
- CYP2C19 poor metabolizers caution
- Suicidality risk
- Concomitant use of CYP2C19 inhibitors caution
Therapeutic Class
- Benzodiazepine hypnotics
Storage Conditions
- Do not use after expiry date
- Store below 30°C
- Protection from light
- Keep out of reach of children