Opsonil 50 mg/2 ml (IM Injection)
2 ml ampoule: ৳ 4.02 (5 x 5: ৳ 100.50)
Medicine Details
| Category | Details |
|---|---|
| Generic | Chlorpromazine hydrochloride |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Schizophrenia and other psychoses (especially paranoid)
- Mania and hypomania
- Anxiety psychomotor agitation excitement
- Intractable hiccup
- Nausea and vomiting of terminal illness
- Childhood schizophrenia and autism
Pharmacology
- Neuroleptic
- Blocks postsynaptic dopamine receptor
- Inhibits release of hypothalamic and hypophyseal hormones
- Antiemetic
- Serotonin-blocking
- Weak antihistaminic properties
- Slight ganglion-blocking activity
Dosage
- Initial dose of 25 mg three times daily or 75 mg at bedtime
- Effective maintenance dose usually in the range of 75 to 300 mg daily
- Intramuscular administration for acute relief of symptoms
- Dosage adjustment for children and elderly based on bodyweight and age
- Different dosage for intractable hiccup and nausea/vomiting of terminal illness
Administration
May be taken with or without food
Interaction
- Interactions resulting in decreased chlorpromazine levels with food, alcohol, and benztropine
- Interactions resulting in increased chlorpromazine levels with tricyclic antidepressants and CYP1A2 inhibitors
Contraindications
- Circulatory collapse
- CNS depression
- Hypersensitivity reaction to phenothiazines
- Bone marrow depression
- Phaeochromocytoma
- Hepatic failure or active hepatic disease
- Allergic-type reactions to sodium metabisulfite and sodium sulfite
Side Effects
- Cardiovascular effects like postural hypotension and ECG changes
- Dermatological reactions
- Endocrine effects like elevated prolactin levels and impaired thermoregulation
- Gastrointestinal effects like dry mouth and constipation
- Immunological reactions
- Genitourinary effects like urinary retention
- Haematological reactions like leucopenia and anaemia
Pregnancy & Lactation
- Pregnancy category C
- Reproductive toxicity in animals
- Inadequate data regarding reproductive toxicity in humans
- Presence in breast milk
Precautions & Warnings
Avoid use in epilepsy, Parkinson's disease, hypoparathyroidism, myasthenia gravis, and prostatic hypertrophy
Use in Special Populations
Elderly are more susceptible to adverse effects
Therapeutic Class
- Anti-emetic drugs
- Phenothiazine drugs
- Phenothiazine related drugs
Storage Conditions
Keep below 30°C, away from light & moisture, and out of the reach of children