Sizonil 5 mg (Tablet)
Unit Price: ৳ 3.50 (10 x 10: ৳ 350.00)
Strip Price: ৳ 35.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trifluoperazine |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Anxiety management
- Nausea and vomiting control
- Management of psychotic disorders
- Treatment of schizophrenia
- Prevention of schizophrenia
- Management of acute psychotic episodes
Pharmacology
- Phenothiazine class compound
- Antagonism at dopamine receptors in the CNS
- Therapeutic actions
- Side effects
- Antipsychotic action in the limbic system
- Antiemetic effect in the medullary chemoreceptor trigger zone
Dosage & Administration
- Recommended starting dose for adults and children over 12 years
- Recommended starting dose for children between 6-12 years
- Dosage adjustment based on child's weight and symptom severity
- Dosage increase based on response
- Dosage reduction for the elderly
- Short-term management of severe anxiety dosage
- Antiemetic dosage
Interaction
- Diminished effect of oral anticoagulants
- Increased plasma levels with concomitant propranolol administration
- Counteraction of antihypertensive effects of guanethidine and related compounds
- Potentiation with CNS depressants
- Interaction with alcohol
- Interaction with hypnotics
- Interaction with anticonvulsants
Contraindications
- Comatose patients
- Patients with blood dyscrasias
- Patients with known liver damage
- Hypersensitivity to the active ingredient or related compounds
Side Effects
- Transient restlessness
- Dystonias
- Parkinsonism-like symptoms
- CNS reactions
- Peripheral edema
- Blood dyscrasias
- Jaundice
- Tachycardia
- Constipation
- Urinary hesitancy
- Retention
- Hyperpyrexia
Pregnancy & Lactation
- Safety during pregnancy not established
- Use in pregnant patients
- Potential benefits outweigh possible hazards
- Reported instances of neonatal effects
- Adequate data not available for lactation
Precautions & Warnings
- Care for elderly patients
- Reduced initial dosage for the elderly
- Sensitivity of elderly patients to extra pyramidal and hypotensive effects
- Caution in patients with cardiovascular disease
- Care for patients with arrhythmias
- Angina pectoris precautions
Overdose Effects
- Predominantly extrapyramidal signs and symptoms
- Possible hypotension
- Gastric lavage treatment
- Supportive and symptomatic measures
- Anticholinergic treatment for extrapyramidal symptoms
- Fluid replacement for hypotension
- Consideration of noradrenaline for severe or persistent hypotension
- Contraindication of adrenaline
Therapeutic Class
- Phenothiazine drugs
Storage Conditions
- Room temperature storage
- Temperature range of 15-30°C
- Protection from light
- Protection from moisture