Sizopin 100 mg (Tablet)

Indications

• Schizophrenia in patients unresponsive to conventional antipsychotic drugs
• Psychosis in Parkinson's disease

Pharmacology

• Atypical antipsychotic drug
• Binds to dopamine receptors
• Affects dopamine-mediated behaviors
• High affinity for the D4 receptor
• Antagonist at adrenergic, cholinergic, histaminergic, and serotonergic receptors

Dosage & Administration

• Initial dosage for schizophrenia in adults over 16 years
• Initial dosage for psychosis in Parkinson's disease
• Gradual dose escalation for well-tolerated doses
• Usual dose range for different conditions
• Instructions for elderly patients

Interaction

• Aggravation of myelosuppression with concomitant use of myelosuppressants
• Interaction with CNS active drugs and alcohol
• Potential for orthostatic hypotension with benzodiazepine usage or other psychotropics
• Impact on plasma levels when used with other drugs
• Recommendations for concomitant administration with specific drugs

Contraindications

• Severe cardiac disorders
• Renal impairment
• History of neutropenia or agranulocytosis
• Bone-marrow disorders
• History of circulatory collapse
• Uncontrolled epilepsy
• Breastfeeding

Side Effects

• Common side effects
• Less common side effects

Pregnancy & Lactation

• Lack of adequate studies in pregnant women
• Potential transfer of the drug in breast milk

Precautions & Warnings

• Recommendation against abrupt medication discontinuation
• Monitoring for adverse effects in elderly patients
• Significant risk of agranulocytosis
• WBC testing frequency and criteria
• Impact on cognitive and motor function
• Potential for benign and severe febrile reactions
• Possible anticholinergic effects
• Risk of hyperglycemia and precautions for patients with diabetes
• Use with caution in patients with hepatic disease or impairment
• Potential for orthostatic hypotension and tachycardia
• Association with myocarditis, pericarditis, and cardiomyopathy
• Rare cases of thromboembolism

Overdose Effects

• Signs and symptoms associated with overdose
• Management of overdose
• Specific considerations for treating hypotension and cardiac arrhythmia
• Lack of specific antidotes
• Potential for delayed effects

Therapeutic Class

• Atypical neuroleptic drugs

Storage Conditions

• Storage temperature
• Protection from light
• Safety measures for children

Related Brands

• Sizopin 25 mg (Tablet) - sun-pharmaceutical-bangladesh-ltd