Zapenia 25 mg (Tablet)
Unit Price: ৳ 2.50 (5 x 10: ৳ 125.00)
Strip Price: ৳ 25.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clozapine |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Schizophrenia treatment
- Psychosis in Parkinson's disease treatment
Pharmacology
- Atypical antipsychotic drug
- Limbic activity
- Receptor binding profile
- Antagonistic effects on adrenergic, cholinergic, histaminergic and serotonergic receptors
Dosage & Administration
- Initial adult dosage of 12.5 mg
- Gradual dosage increase
- Maximum adult dosage of 900 mg daily
- Dosage based on response and age
- Single and divided doses
- Maximum bedtime dosage
Interaction
- Aggravated myelosuppression with concomitant myelosuppressants
- Interaction with CNS active drugs and alcohol
- Potential displacement of protein-bound drugs
- Interactions with selective drugs like cimetidine, carbamazepine, fluvoxamine, paroxetine, sertraline, adrenaline, and cytochrome P450 2D6 metabolized drugs
Contraindications
- Severe cardiac disorders
- Renal impairment
- Neutropenia or agranulocytosis history
- Bone-marrow disorders
- Paralytic ileus
- Alcoholic and toxic psychoses
- Circulatory collapse history
- Uncontrolled epilepsy
- Breastfeeding
Side Effects
- Constipation
- Dizziness or lightheadedness
- Drowsiness
- Headache
- Increased watering of mouth
- Nausea or vomiting
- Unusual weight gain
- Abdominal discomfort or heartburn
- Dryness of mouth
Pregnancy & Lactation
- Unstudied effects in pregnant women
- Potential secretion in breast milk
- Restriction on nursing for women taking the drug
Precautions & Warnings
- Tapered medication cessation
- Abrupt discontinuation monitoring
- Elderly susceptibility to adverse effects
- Significant risk of agranulocytosis
- Regular WBC testing
- Caution in patients at risk of seizures
- Benign fever and severe febrile reactions potential
- Anticholinergic effects caution
- Hyperglycemia monitoring
- Hepatic disease caution
- Orthostatic hypotension and tachycardia caution
- Myocarditis, cardiomyopathy, and CHF risks and monitoring
- Thromboembolism caution
- Eosinophilia caution
Overdose Effects
- Altered states of consciousness
- Tachycardia
- Hypotension
- Respiratory depression or failure
- Hypersalivation
- Seizures
- Potential fatal overdoses
- Management through airway maintenance, oxygenation, and ventilation
- Activated charcoal usage
- Cardiac and vital signs monitoring
- Absence of specific antidotes
- Unlikely benefits from diuresis, dialysis, hemoperfusion, and exchange transfusion
Therapeutic Class
- Atypical neuroleptic drugs
Storage Conditions
- Maximum storage temperature of 30°C
- Protection from light
- Keep out of the reach of children