Amilax 0.5 mg+10 mg (Tablet)

Indications

• Anxiety
• Depression
• Apathy
• Psychogenic depression
• Depressive neurosses
• Masked depression
• Psychosomatic affections accompanied by anxiety and apathy
• Menopausal depressions
• Dysphoria and depression in alcoholics and drug addicts

Pharmacology

• Contains flupentixol - a neuroleptic with anxiolytic and antidepressant properties
• Contains melitracen - a bipolar thymoleptic with activating properties
• Maximal serum concentration reached in about 4 hours
• Biological half-life of flupentixol is about 35 hours
• Biological half-life of melitracen is about 19 hours
• Combination renders preparation with antidepressant, anxiolytic, and activating properties

Dosage & Administration

• Adults: Usually 2 tablets orally daily in the morning and noon
• In severe cases, morning dose may be increased to 2 tablets
• Elderly patients: 1 tablet in the morning
• Maintenance dose: Usually 1 tablet orally in the morning
• Additional treatment with a sedative in acute phase recommended for insomnia or severe restlessness

Interaction

• May enhance response to alcohol, barbiturates, and other CNS depressants
• Simultaneous administration of MAO-inhibitors may cause hypertensive crises
• Neuroleptics and thymoleptics reduce antihypertensive effect of guanethidine and similar acting compounds
• Thymoleptics enhance effects of adrenaline and noradrenaline

Contraindications

• Immediate recovery phase after myocardial infarction
• Defects in bundle-branch conduction
• Untreated narrow-angle glaucoma
• Acute alcohol, barbiturate, and opiate intoxications
• Not to be given to patients who have received an MAO-inhibitor within two weeks
• Not recommended for excitable or overactive patients

Side Effects

• Rare in recommended doses
• Transient restlessness
• Insomnia

Pregnancy & Lactation

• Preferably not to be given during pregnancy and lactation

Precautions & Warnings

• Tranquilizers with sedative effect should be withdrawn gradually

Overdose Effects

• Symptoms of intoxications by melitracen dominate in cases of overdosage
• Extrapyramidal symptoms due to flupentixol occur more rarely
• Symptomatic and supportive measures recommended
• Gastric lavage should be carried out as soon as possible
• Activated charcoal may be administered
• Measures aimed at supporting the respiratory and cardiovascular systems should be instituted
• Epinephrine (adrenaline) must not be used for such patients
• Convulsions may be treated with diazepam
• Extrapyramidal symptoms with biperiden

Therapeutic Class

• Combined anxiolytics & antidepressant drugs

Storage Conditions

• Store at a temperature not exceeding 30°C in a dry place
• Protect from light
• Keep out of reach of children

Common Questions about Amilax 0.5 mg Tablet

• Consists of Flupentixol & Melitracen
• Used to treat Anxiety, Depression, Apathy, Psychogenic depression, Depressive neurosses, Masked depression, Menopausal depressions
• Helps treat anxiety and depression
• Can cause dizziness and sleepiness
• Avoid drinking alcohol while taking
• Can cause changes in blood sugar levels
• Inform doctor if liver disease, thyroid disorder, severe heart disease, or urinary disorder
• Talk to doctor if notice sudden mood changes or develop suicidal thoughts
• Inform doctor before undergoing any surgical procedure

Related Brands

• Adelax 0.5 mg+10 mg (Tablet) - aci-limited