Leanxit 0.5 mg+10 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Flupentixol melitracen |
| Company | Acme laboratories ltd |
Title
Flupentixol and Melitracen Tablet
Categories
- Anxiolytics & Anti-depressants
- Pharmacology
- Dosage & Administration
- Drug Interactions
- Contraindications
- Side Effects
- Pregnancy & Lactation
- Precautions & Warnings
- Overdose Effects
- Therapeutic Class
- Storage Conditions
Description
Flupentixol and Melitracen tablet is indicated for anxiety, depression, apathy, psychogenic depression, depressive neurosses, masked depression, menopausal depressions, dysphoria and depression in alcoholics and drug addicts. It contains flupentixol with anxiolytic and antidepressant properties and melitracen with activating properties. The usual adult dosage is 2 tablets orally daily in the morning and noon. It may enhance the response to alcohol, barbiturates and other CNS depressants and interact with MAO-inhibitors. Contraindications include immediate recovery phase after myocardial infarction, untreated narrow-angle glaucoma, and acute alcohol, barbiturate and opiate intoxications. Side effects are rare but may include transient restlessness and insomnia. It should preferably not be given during pregnancy and lactation. Precautions should be taken with patients previously treated with tranquillizers with sedative effect. In cases of overdosage, symptoms of intoxications by melitracen may dominate, supported by symptomatic and supportive measures. It belongs to the therapeutic class of combined anxiolytics & anti-depressant drugs. Store at a temperature not exceeding 30°C in a dry place, protected from light, and out of reach of children.
Indications
- Anxiety
- Depression
- Apathy
- Psychogenic depression
- Depressive neurosses
- Masked depression
- Psychosomatic affections accompanied by anxiety and apathy
- Menopausal depressions
- Dysphoria and depression in alcoholics and drug addicts
Pharmacology
Combination of flupentixol and melitracen with antidepressant, anxiolytic, and activating properties. Maximal serum concentration is reached in about 4 hours after oral administration of each compound. Biological half-life of flupentixol is about 35 hours and that of melitracen is about 19 hours.
Dosage & Administration
- Adults: Usually 2 tablets orally daily in the morning and noon. In severe cases, the morning dose may be increased to 2 tablets.
- Elderly patients: 1 tablet in the morning.
- Maintenance dose: Usually 1 tablet orally in the morning. In cases of insomnia or severe restlessness, additional treatment with a sedative in the acute phase is recommended.
Interaction
May enhance the response to alcohol, barbiturates, and other CNS depressants. Simultaneous administration of MAO-inhibitors may cause hypertensive crises. Neuroleptics and thymoleptics reduce the antihypertensive effect of certain compounds and thymoleptics enhance the effects of adrenaline and noradrenaline.
Contraindications
- Immediate recovery phase after myocardial infarction
- Defects in bundle-branch conduction
- Untreated narrow-angle glaucoma
- Acute alcohol, barbiturate, and opiate intoxications
- Patients who have received an MAO-inhibitor within two weeks
- Not recommended for excitable or overactive patients
Side Effects
- Transient restlessness
- Insomnia
Pregnancy & Lactation
Preferably not given during pregnancy and lactation.
Precautions & Warnings
Withdraw tranquillizers with sedative effect gradually if previously treated.
Overdose Effects
Symptoms of intoxications by melitracen, especially of anticholinergic nature, may dominate. Measures aimed at supporting the respiratory and cardiovascular systems should be instituted.
Therapeutic Class
Combined anxiolytics & anti-depressant drugs
Storage Conditions
Store at a temperature not exceeding 30°C in a dry place. Protect from light. Keep out of reach of children.