Olanap 5 mg (Tablet)

Unit Price: ৳ 2.50 (5 x 10: ৳ 125.00)
Strip Price: ৳ 25.00

Medicine Details

Category Details
Generic Olanzapine
Company Incepta pharmaceuticals ltd
Also available as
Olanap 10 mg tablet Olanap odt 10 mg tablet Olanap odt 5 mg tablet

Indications

  • Treatment of schizophrenia
  • Treatment of related psychoses
  • Treatment of bipolar disorder
  • Treatment of manic episodes
  • Treatment of mixed episodes
  • Maintenance therapy
  • Treatment of positive symptoms
  • Treatment of negative symptoms

Pharmacology

  • Affinities for serotonin 5HT2A/2C, 5HT3, 5HT6
  • Affinities for dopamine D1, D2, D3, D4, D5
  • Affinities for cholinergic muscarinic receptors M1-M5
  • Affinities for α1 adrenergic and histamine H1 receptors
  • Mechanism of action unknown
  • Proposed efficacy through dopamine and serotonin type 2 (5HT2) antagonism
  • Well absorbed after oral administration
  • Peak plasma concentrations within 5 to 8 hours
  • Absorption not affected by food
  • Not mutagenic or clastogenic
  • Not carcinogenic

Dosage

  • Initial dose 5-10 mg once daily for schizophrenia and bipolar disorder
  • Daily dosage may be adjusted within the range of 5-20 mg daily
  • Maximum dose is 20 mg daily
  • Initial dose 15 mg once daily for monotherapy for mania
  • Maximum dose for monotherapy is 20 mg daily

Administration

  • Can be given without regard to meals
  • Gradual tapering of the dose should be considered while discontinuing

Interaction

  • Antagonizes effects of levodopa and dopamine agonists
  • Influenced by drugs that induce CYP1A2 or glucoronyl transferase enzymes
  • Inhibitors of CYP1A2 may potentially inhibit elimination
  • Carbamazepine may increase clearance
  • Activated charcoal reduces oral bioavailability by 50-60%
  • Caution required with centrally acting drugs and alcohol

Contraindications

  • Known hypersensitivity to any ingredient
  • Known risk for narrow-angle glaucoma

Side Effects

  • Somnolence
  • Weight gain
  • Increased appetite
  • Elevated glucose levels
  • Elevated triglyceride levels
  • Dizziness
  • Akathisia
  • Parkinson's disease
  • Dyskinesia
  • Orthostatic hypotension
  • Anticholinergic effects including constipation and dry mouth
  • Asthenia
  • Edema
  • Photosensitivity reaction

Pregnancy & Lactation

  • Use in pregnancy if potential benefits justify potential risk to the foetus
  • Patients advised to notify physician if pregnant or intending to become pregnant
  • No report to show teratogenicity
  • Breastfeeding not advised

Precautions & Warnings

  • Cautious use in patients with history of seizures
  • Cautious use in patients with low leukocyte and/or neutrophil counts
  • Cautious use in patients with impaired hepatic function
  • Cautious use in patients using hepatotoxic medicines
  • Cautious use in patients using centrally acting drugs
  • Cautious use in patients using medicines known to increase QT interval
  • Cautious use in the elderly
  • Patients cautioned about operating hazardous machinery

Use in Special Populations

  • Not studied in subjects under 18 years of age
  • Starting dose of 5 mg/day for elderly patients
  • Starting dose of 5 mg/day for patients with hepatic or renal impairment

Therapeutic Class

  • Atypical neuroleptic drugs

Storage Conditions

  • Keep below 30°C temperature
  • Keep away from light and moisture
  • Keep out of the reach of children

Related Brands