Oleanz 10 mg (Tablet)
Unit Price: ৳ 4.56 (5 x 10: ৳ 228.00)
Strip Price: ৳ 45.60
Medicine Details
| Category | Details |
|---|---|
| Generic | Olanzapine |
| Company | Sun pharmaceutical bangladesh ltd |
| Also available as |
Indications
- Acute treatment of schizophrenia
- Maintenance treatment of schizophrenia
- Treatment of related psychoses
- Treatment of positive symptoms in schizophrenia
- Treatment of negative symptoms in schizophrenia
- Treatment of acute manic episodes in bipolar disorder
- Treatment of mixed episodes in bipolar disorder
Pharmacology
- Affinities for serotonin 5HT2A/2C, 5HT3, 5HT6 receptors
- Affinities for dopamine D1, D2, D3, D4, D5 receptors
- Affinities for cholinergic muscarinic receptors M1-M5
- Affinities for α1 adrenergic and histamine H1 receptors
- Mechanism of action unknown
- Proposed efficacy through dopamine and serotonin type 2 antagonism
- Well absorbed after oral administration
- Peak plasma concentrations within 5 to 8 hours
Dosage
- Initial dose 5-10 mg once daily
- Subsequent dosage adjustments based on clinical status
- Maximum dose of 20 mg daily
Administration
- Can be given without regard to meals
- Gradual tapering of the dose recommended while discontinuing
Interaction
- May antagonize effects of levodopa and dopamine agonists
- Inducers of CYP1A2 or glucoronyl transferase enzymes may increase clearance
- Inhibitors of CYP1A2 may inhibit elimination
- Carbamazepine may increase clearance
- Activated charcoal reduces oral bioavailability by 50-60%
- Caution with centrally acting drugs and alcohol
Contraindications
- Hypersensitivity to any ingredient
- Known risk for narrow-angle glaucoma
Side Effects
- Very common: somnolence and weight gain
- Other effects: increased appetite, elevated glucose levels, elevated triglyceride levels, dizziness, akathisia, Parkinson's disease, dyskinesia, orthostatic hypotension, anticholinergic effects, asthenia, edema, photosensitivity reaction
Pregnancy & Lactation
- Use in pregnancy if potential benefits justify potential risk to the foetus
- Patients advised to notify physician if pregnant or intending to become pregnant during treatment
- No reported teratogenicity
- Patients advised not to breastfeed while taking Olanzapine
Precautions & Warnings
- Caution in patients with history of seizures
- Caution in patients with low leukocyte and/or neutrophil counts for any reason
- Caution in patients with impaired hepatic function
- Caution in patients using hepatotoxic medicines
- Caution in patients using centrally acting drugs
- Caution in patients using medicines known to increase QT interval
- Caution in elderly patients operating hazardous machinery or vehicles
Use in Special Populations
- Not studied in subjects under 18 years of age
- Starting dose for elderly patients (age 65 and over): 5 mg/day
- Starting dose for patients with hepatic or renal impairment: 5 mg/day
Therapeutic Class
- Atypical neuroleptic drugs
Storage Conditions
- Keep below 30°C
- Keep away from light and moisture
- Keep out of the reach of children