Qpine 100 mg (Tablet)

Unit Price: ৳ 10.07 (3 x 10: ৳ 302.10)
Strip Price: ৳ 100.70

Medicine Details

Indications

  • Treatment of acute and chronic psychoses
  • Treatment of schizophrenia
  • Treatment of bipolar disorder
  • Maintenance treatment of bipolar I disorder
  • Prevention of recurrence of manic, depressive or mixed episodes

Pharmacology

  • Belongs to dibenzothiazepine derivatives chemical class
  • Antagonist at neurotransmitter receptors
  • Targets serotonin, dopamine, histamine, and adrenergic receptors
  • Mechanism of action is unknown

Dosage & Administration

  • Twice-daily administration for acute and chronic psychoses and schizophrenia
  • Once or twice-daily administration for bipolar disorder
  • Total daily dose range of 150 to 750 mg for acute and chronic psychoses and schizophrenia
  • Usual effective dose range of 300-450 mg/day for acute and chronic psychoses and schizophrenia
  • Total daily dose range of 200 to 800 mg for manic episodes associated with bipolar disorder
  • Usual effective dose range of 400 to 800 mg/day for manic episodes associated with bipolar disorder
  • Usual dose of 300 mg/day for depressive episodes associated with bipolar disorder
  • Usual dose range of 400 to 600 mg/day for depressive episodes associated with bipolar disorder
  • Usual dose range of 400 to 800 mg/day for maintenance treatment of bipolar I disorder

Interaction

  • Potential interaction with medicines causing electrolyte imbalance
  • Potential interaction with medicines increasing QT interval
  • Potential interaction with thioridazine, carbamazepine, and phenytoin

Contraindications

  • Contra-indicated in patients hypersensitive to it

Side Effects

  • Common adverse drug reactions include somnolence, dizziness, dry mouth, and weight gain

Pregnancy & Lactation

  • Safety and efficacy during human pregnancy not established
  • Use only if benefits justify potential risks
  • Avoid breastfeeding while taking the medication

Precautions & Warnings

  • Increased risk of suicidal thoughts and self-harm in patients with depression
  • Use with caution in patients with cardiovascular or cerebrovascular disease
  • Caution in patients with history of seizures
  • Consider dose reduction or discontinuation if signs of tardive dyskinesia appear
  • Discontinue in case of neuroleptic malignant syndrome
  • Exercise caution in patients with a history of QT prolongation or cardiovascular disease
  • Monitor for neutropenia and hyperglycemia

Use in Special Populations

  • Use with caution in the elderly
  • Not indicated for use in children and adolescents below 18 years of age

Overdose Effects

  • Survival reported in acute overdoses of up to 30 grams
  • No specific antidote available
  • Intensive care procedures recommended
  • Treat refractory hypotension with appropriate measures

Therapeutic Class

  • Atypical neuroleptic drugs

Storage Conditions

  • Keep out of sight and reach of children
  • Do not use after expiry date
  • Store in a cool, dry place away from light

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