Seroquet 25 mg (Tablet)
Unit Price: ৳ 3.00 (3 x 10: ৳ 90.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Quetiapine fumarate |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of Acute and chronic psychoses
- Treatment of schizophrenia
- Treatment of Bipolar Disorder
- Maintenance treatment of bipolar I disorder
- Combination therapy with a mood stabilizer
- Treatment of manic episodes satisfying DSM-IV criteria
- Treatment of depressive episodes associated with bipolar disorder
- Prevention of recurrence of manic, depressive or mixed episodes
Pharmacology
- Belongs to a chemical class, the dibenzothiazepine derivatives
- Antagonist at multiple neurotransmitter receptors in the brain
- Antagonist at serotonin 5HT1A and 5HT2 receptors
- Antagonist at dopamine D1 and D2 receptors
- Antagonist at histamine H1 receptor
- Antagonist at adrenergic α1 and α2 receptors
- No appreciable affinity at cholinergic muscarinic and benzodiazepine receptors
Dosage & Administration
- Total daily dose for the first four days of therapy
- Usual effective dose range
- Dosage adjustments
- Administration frequency
- Administration with or without food
- Titration of dose
Interaction
- Caution with medicines known to cause electrolyte imbalance
- Caution with medicines known to increase QT interval
- Co-administration with thioridazine or carbamazepine
- Co-administration with phenytoin
- Increases in the clearance of Seroquet
Contraindications
- Hypersensitivity to Quetiapine
Side Effects
- Somnolence
- Dizziness
- Dry mouth
- Withdrawal symptoms
- Elevations in serum triglyceride levels
- Elevations in total cholesterol
- Decreases in HDL cholesterol
- Weight gain
- Decreased haemoglobin
- Extrapyramidal symptoms
Pregnancy & Lactation
- Safety and efficacy during human pregnancy not established
- Use during pregnancy if benefits justify potential risks
- Lowest possible dose and duration of treatment during pregnancy
- Excretion into human milk is unknown
- Avoid breastfeeding while taking Quetiapine
Precautions & Warnings
- Risk of suicidal thoughts and self-harm
- Caution in patients with known cardiovascular disease
- Caution in patients with cerebrovascular disease
- Caution in patients predisposed to hypotension
- Caution in patients with history of seizures
- Consideration of dose reduction or discontinuation for tardive dyskinesia
- Discontinuation and appropriate medical treatment for Neuroleptic Malignant Syndrome
- Caution in patients with cardiovascular disease or family history of QT prolongation
- Reports of severe neutropenia
- Observation of increases in blood glucose and hyperglycemia
Use in Special Populations
- Caution in the elderly
- Slower rate of dose titration in the elderly
- Lower daily therapeutic dose in the elderly
- Not indicated for use in children and adolescents below 18 years of age
Overdose Effects
- Reported survival in acute overdoses of up to 30 grams of Seroquet
- No specific antidote to Seroquet
- Consideration of multiple drug involvement in severe intoxication
- Intensive care procedures recommended
- Treatment of refractory hypotension with appropriate measures
- Close medical supervision and monitoring
Therapeutic Class
- Atypical neuroleptic drugs
Storage Conditions
- Keep out of the sight and reach of children
- Do not use after the expiry date
- Store in a cool and dry place
- Away from light