Riscord 4 mg (Tablet)

Unit Price: ৳ 9.00 (4 x 10: ৳ 360.00)

Strip Price: ৳ 90.00

Medicine Details

Category	Details
Generic	Risperidone oral
Company	General pharmaceuticals ltd
Also available as	Riscord 2 mg tablet Riscord 1 mg tablet

Indications

Acute and chronic psychoses
Mania
Schizophrenia

Pharmacology

Risperidone is a selective monoaminergic antagonist having a high affinity for serotoninergic 5-HT2 and dopaminergic D2 receptors. Risperidone binds also to alpha1 adrenergic receptors and with lower affinity, to H1 histamine and alpha2 adrenergic receptors. Risperidone has no affinity for 8 cholinergic receptors. Risperidone, as a potent D2 antagonist, improves the positive symptoms of schizophrenia but causes less depression of motor activity. Balanced central serotonin and dopamine antagonism may reduce extrapyramidal side effect liability and extend the therapeutic activity to the negative and affective symptoms of schizophrenia.

Dosage & Administration

2 mg in 1-2 divided doses on 1st day then 4 mg in 1-2 divided doses on second day (Slower titration appropriate in some patients)
Usual dose range 4-6 mg daily
Elderly (or in hepatic or renal impairment) initially 1 mg daily in two divided doses increased in steps of 1-2 mg twice daily
Child under 15 years not recommended
Initial dosage for mania is 2 mg once daily, increased if necessary in step of 1 mg daily, usual dose range 1-6 mg daily
Elderly (or in hepatic or renal impairment) initially 1 mg daily in two divided doses increased in steps of 1-2 mg twice daily
Initial dosage for schizophrenia is 1 mg BID initially, with increases in increments of 1 mg BID on the second and third day, as tolerated, to a target dose of 3 mg BID by the third day
Further dosage adjustments, if indicated, should generally occur at intervals of not less than 1 week, with small dose increments/decrements of 1-2 mg recommended

Interaction

Riscord May antagonize the effects of levodopa and dopamine agonists. Chronic administration with Carbamazepine reduces plasma clearance of Riscord. Chronic administration with Clozapine may decrease the clearance of Riscord. Riscord may enhance the effects of certain antihypertensives

Contraindications

Risperidone is contraindicated in patients with a known hypersensitivity to the product

Side Effects

Insomnia
Agitation
Anxiety
Headache
Drowsiness
Impaired concentration
Fatigue
Blurred vision
Constipation
Nausea and vomiting
Dyspepsia
Abdominal pain
Hyperprolactinaemia
Urine incontinence
Tachycardia
Hypertension
Edema
Rash
Rhinitis
Cerebrovascular accident
Neurtropenia
Thrombocytopenia

Pregnancy & Lactation

The safety of Risperidone for use during human pregnancy has not been established. Risperidone and 9-hydroxyrisperidone are excreted in the milk, therefore, women receiving Risperidone should not breastfeed.

Precautions & Warnings

Special precaution should be taken in case of preexisting cardiovascular diseases, discontinue use if signs and symptoms of tardive dyskinesia occur, renal and hepatic impairment, elderly epilepsy, Parkinson's disease, and in pregnancy