Lithin SR 400 mg (Tablet (Sustained Release))

Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Lithium carbonate
Company Incepta pharmaceuticals ltd

Title

  • Lithium Carbonate Tablets

Categories

  • Medicine
  • Psychiatric Medication
  • Mood Stabilizer

Description

  • Used for the treatment and prophylaxis of mania, bipolar disorder, and recurrent depression

DosageAdministration

  • Initial dosage of 1 gm to 1.5 gm daily for adults and children over 12 years
  • Prophylaxis dosage of initially 300-400 mg daily
  • Should be taken with food

ModeOfAction

  • Mechanism of action still unknown
  • Therapeutic action may be due to inhibition of enzymes such as glycogen synthase kinase 3
  • Modulation of glutamate receptors
  • Alters intraneuronal metabolism of catecholamines and sodium transport in neurons and muscle cells

Interaction

  • Reduced serum levels with carbonic anhydrase inhibitors, chlorpromazine, sodium-containing preparations, theophylline, urea
  • Enhanced hypothyroid effects with iodine salts
  • Enhanced effects of neuromuscular-blocking agents
  • Reduced pressor response to sympathomimetics

Contraindications

  • Renal insufficiency
  • Cardiovascular insufficiency
  • Addison's disease
  • Untreated hypothyroidism

SideEffects

  • Tiredness
  • Loss of appetite
  • Nausea
  • Vomiting
  • Diarrhoea
  • Hands shaking
  • Memory problems
  • Increased thirst
  • More frequent urination by day and night

PregnancyLactation

  • Pregnancy Category D
  • Increased incidence of cardiovascular abnormality in infants if taken during the first 3 months of pregnancy
  • Breastfeeding not advised unless benefits outweigh the advantages

PrecautionsWarnings

  • Decreased tolerance with protracted sweating or diarrhoea
  • Supplemental fluid and salt may be needed under medical supervision
  • Careful monitoring if such conditions occur

SpecialPopulations

  • Renal Impairment: Adjust dose based on creatinine clearance (CrCl)

OverdoseEffects

  • Stop lithium in case of accumulation
  • Frequent serum estimations
  • Avoid diuretics
  • Consider osmotic diuresis or alkalinisation of urine if necessary
  • Peritoneal or hemodialysis if serum lithium level is over 4.0 mmol/L
  • Monitor serum lithium levels for at least a week after therapy

TherapeuticClass

  • Anti-manic drugs

StorageConditions

  • Store at 25°C

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