Pinor 25 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Imipramine hydrochloride |
| Company | Aristopharma ltd |
Indications
- Depressive illness
- Nocturnal enuresis in children
Description
An original tricyclic antidepressant and a member of the dibenzazepine group of compounds. Its mechanism of action is not definitely known, but it does not act primarily by stimulation of the central nervous system. The clinical effect is hypothesized as being due to the potentiation of adrenergic synapses by blocking uptake of norepinephrine at nerve endings.
Pharmacology
Works by inhibiting the neuronal reuptake of the neurotransmitters norepinephrine and serotonin. It binds the sodium-dependent serotonin transporter and sodium-dependent norepinephrine transporter, reducing the reuptake of norepinephrine and serotonin by neurons.
Dosage & Administration
- Initiate up to 75 mg daily in divided doses, gradually increased to 150-200 mg (up to 300 mg in hospital patients)
- Up to 150 mg may be given as a single dose at bedtime
- Elderly initially 10 mg daily, gradually increased to 30-50 mg daily
- Not recommended for depression in children
- For nocturnal enuresis: Child 7-8 years: 25 mg, 8-11 years: 25-50 mg, Over 11 years: 50-75 mg at bedtime; max
- Period of treatment (including gradual withdrawal): 3 months-full physical examinations before the further course
Interaction
Methylphenidate may increase the effects of imipramine. Imipramine may increase the depressant action of alcohol. Dangerously high blood pressure has resulted from the combination of imipramine and monoamine oxidase (MAO) inhibitors. The anticholinergic effects of imipramine are additive with other anticholinergic drugs.
Contraindications
- Should not be given in conjunction with, or within 14 days of treatment with a MAO inhibitor
- Contraindicated in patients with existing severe hepatic or renal damage, a history of blood dyscrasias, hypersensitivity to the drug or tricyclic antidepressants belonging to the dibenzazepine group, during the acute recovery phase following myocardial infarction, convulsive disorders or glaucoma
Side Effects
- Dry mouth
- Constipation
- Urinary retention
- Increased heart rate
- Sedation
- Irritability
- Dizziness
- Decreased coordination
- Changes in blood pressure and heart rate
- Confusion
- Insomnia
- Anxiety
- Skin problems
- Seizures
- Ringing in the ears
- Nausea
- Vomiting
- Loss of appetite
- Diarrhea
- Abdominal cramping
Pregnancy & Lactation
Pregnancy category D. Limited data suggest that imipramine is likely to be excreted in human breast milk. Known risk of damage to fetus.
Precautions & Warnings
Should be used cautiously and with close physician supervision in people with benign prostatic hypertrophy, urinary retention, and glaucoma. The sedative effect is increased when taken with other central nervous system depressants. May increase heart rate and stress on the heart. Dangerous for people with cardiovascular disease, especially those who have recently had a heart attack. Close monitoring for signs of suicide is necessary. The risk of suicide is increased when imipramine is taken in overdose or combined with alcohol. Manic episodes and the emergence of symptoms of pre-existing psychotic states have been reported when imipramine therapy is started.
Overdose Effects
Children have been reported to be more sensitive than adults to an acute overdose of imipramine. An acute overdose in infants or young children must be considered serious and potentially fatal.
Therapeutic Class
Tricyclic & related antidepressant drugs, Tricyclic Antidepressant
Storage Conditions
Keep below 30°C temperature, away from light and moisture. Keep out of the reach of children.