Pramin 25 mg (Tablet)
Unit Price: ৳ 4.00 (5 x 10: ৳ 200.00)
Strip Price: ৳ 40.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Imipramine hydrochloride |
| Company | Incepta pharmaceuticals ltd |
Indications
- Depressive illness
- Nocturnal enuresis in children
Description
- Tricyclic antidepressant
- Dibenzazepine compound
- Mechanism of action not fully known
- Potentiates adrenergic synapses
- Blocks uptake of norepinephrine
Pharmacology
- Inhibits neuronal reuptake of norepinephrine and serotonin
- Binds sodium-dependent serotonin transporter
- Reduces reuptake of neurotransmitters
- Linked to changes in neurotransmission and brain physiology
Dosage & Administration
- Initial dosage up to 75 mg daily
- Increased gradually to 150-200 mg
- Up to 300 mg in hospital patients
- Up to 150 mg may be given as a single bedtime dose
- Elderly initial dosage 10 mg daily
- Child not recommended for depression
- Children's dosage for nocturnal enuresis by age
Interaction
- Methylphenidate may increase effects
- May increase depressant action of alcohol
- Dangerously high blood pressure with MAO inhibitors
- Anticholinergic effects are additive with other drugs
Contraindications
- Do not use with MAO inhibitors
- Contraindicated in severe hepatic or renal damage
- Contraindicated in history of blood dyscrasias
- Hypersensitivity to the drug or tricyclic antidepressants
- Not for use during acute recovery phase after myocardial infarction
- Not for use in convulsive disorders or glaucoma
Side Effects
- Dry mouth
- Constipation
- Urinary retention
- Increased heart rate
- Sedation
- Irritability
- Dizziness
- Decreased coordination
- Changes in blood pressure and heart rate
- Heart-related issues
- Confusion and disorientation
- Skin problems
- Seizures
- Ringing in the ears
- Gastrointestinal effects
Pregnancy & Lactation
- Pregnancy category D
- Excreted in human breast milk
- Known risk of damage to fetus
Precautions & Warnings
- Cautious use in elderly with specific conditions
- Increased sedative effects with CNS depressants
- Increased heart rate and stress on the heart
- Risk for cardiovascular disease patients
- Need for close monitoring during initial dosage
- Risk of suicide especially in overdose or with alcohol
- Emergence of pre-existing psychotic states
Overdose Effects
- Children more sensitive than adults
- Serious and potentially fatal overdose in infants or young children
Therapeutic Class
- Tricyclic & related anti-depressant drugs
- Tricyclic Anti-depressant
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children