Tofranil 25 mg (Tablet)

Unit Price: ৳ 5.60 (10 x 10: ৳ 560.00)

Strip Price: ৳ 56.00

Medicine Details

Category	Details
Generic	Imipramine hydrochloride
Company	Sandoz a novartis division

An original tricyclic antidepressant
Member of the dibenzazepine group of compounds
Mechanism of action not definitely known
Hypothesized clinical effect due to potentiation of adrenergic synapses by blocking uptake of norepinephrine at nerve endings

Initial dose up to 75 mg daily in divided doses
Can be increased gradually to 150-200 mg
Up to 300 mg in hospital patients
Up to 150 mg may be given as a single dose at bedtime
Elderly initial dose 10 mg daily, increased gradually to 30-50 mg daily
Child dosage for nocturnal enuresis: 7-8 years 25 mg, 8-11 years 25-50 mg, over 11 years 50-75 mg at bedtime
Period of treatment (including gradual withdrawal): 3 months with full physical examinations before the further course

Works by inhibiting the neuronal reuptake of neurotransmitters norepinephrine and serotonin
Binds the sodium-dependent serotonin transporter and sodium-dependent norepinephrine transporter
Reduces the reuptake of norepinephrine and serotonin by neurons
Increases concentration in the synaptic cleft, producing knock-on effects in protein kinase signaling which is thought to contribute to changes in neurotransmission and brain physiology relieving symptoms of depression

Methylphenidate may increase effects of imipramine, usually avoided by reducing imipramine dosage
Tofranil may increase the depressant action of alcohol
Dangerously high blood pressure resulted from combination of imipramine and MAO inhibitors
Anticholinergic effects of imipramine are additive with other anticholinergic drugs like benztropine, biperiden, and antihistamines

Not to be given in conjunction with or within 14 days of treatment with MAO inhibitors
Contraindicated in patients with severe hepatic or renal damage
Contraindicated in patients with a history of blood dyscrasias
Contraindicated in patients showing hypersensitivity to the drug or tricyclic antidepressants belonging to the dibenzazepine group
Contraindicated during acute recovery phase following myocardial infarction
Not to be used in patients with convulsive disorders or glaucoma

Use cautiously with benign prostatic hypertrophy, urinary retention, and glaucoma
Increased sedative effect when taken with other central nervous system depressants
May increase heart rate and stress on the heart
Dangerous for people with cardiovascular disease
Close monitoring for signs of suicide
Increased risk of suicide when taken in overdose or combined with alcohol
Manic episodes and emergence of symptoms of pre-existing psychotic states reported

Children reported to be more sensitive than adults to acute overdosage, considered serious and potentially fatal