Nortin 10 mg (Capsule)
Unit Price: ৳ 2.50 (10 x 10: ৳ 250.00)
Strip Price: ৳ 25.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Nortriptyline |
| Company | Navana pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of depression
- Treatment of nocturnal enuresis
Pharmacology
- Nortriptyline as primary active metabolite of amitriptyline
- Increases synaptic concentration of serotonin and/or norepinephrine in the CNS
- Blocks the neuronal reuptake of norepinephrine and serotonin
Dosage & Administration
- Adult dosage: Low dose initially, increased as necessary to 75-100 mg daily
- Adolescent & Elderly dosage: 30-50 mg daily
- Child dosage for nocturnal enuresis: 10 mg for 7-year-olds, 10-20 mg for 8-11 year-olds, 25-35 mg for over 11 year-olds
- Max period of treatment for nocturnal enuresis: 3 months
Interactions
- Not to be given with adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine, phenylpropanolamine, drugs metabolized by CYP4502D6, MAOIs, guanethidine, debrisoquine, bethanidine, clonidine, and reserpine
- Barbiturates may increase the rate of metabolism
Contraindications
- Hypersensitivity to nortriptyline
- Concomitant administration with MAOI
- During the acute recovery period after myocardial infarction
Side Effects
- Dry mouth
- Sedation
- Constipation
- Increased appetite
- Mild blurred vision
- Tinnitus
- Euphoria and mania
- Rapid or irregular heartbeat
Pregnancy & Lactation
- Safety not established for use in pregnancy
- Should only be given during pregnancy when there are no alternatives and benefit outweighs risk
Precautions & Warnings
- Not intended for treatment of bipolar depression
- Avoid abrupt withdrawal
- Patient at risk of seizures, with DM, narrow angle glaucoma, urinary retention, prostatic hyperplasia, chronic constipation, history of CV disease
- Renal and hepatic impairment
- Elderly, children
- Pregnancy and lactation
Overdose Effects
- Symptoms: Severe hypotension, cardiac dysrhythmias, shock, CHF, pulmonary edema, convulsions, CNS depression, coma
- Management: Symptomatic and supportive treatment, IV Na bicarbonate, benzodiazepines, activated charcoal, cardiac monitoring, observation for signs of CNS or resp depression, hypotension, cardiac dysrhythmias, conduction blocks, seizures
Therapeutic Class
- Tricyclic & related antidepressant drugs
- Tricyclic antidepressant
Storage Conditions
- Store at 15-30°C
- Protect from light and moisture